灵芝Ganoderma具有扶正固本、补气安神、延年益寿等功效。现代临床中常采用灵芝与多味中药配伍用于抗肿瘤。近年来研究发现，灵芝的抗肿瘤机制主要涉及调节机体免疫、阻滞细胞周期、诱导肿瘤细胞凋亡和自噬、抑制肿瘤细胞转移以及抗氧化等。通过对灵芝抗肿瘤作用的分子机制和与灵芝配伍的抗肿瘤作用机制进行综述，为灵芝抗肿瘤的临床应用提供参考。

Lingzhi (Ganoderma) has the ability to reinforce healthy qi and consolidate the root, nourish qi and calm the mind, and prolong life. In modern clinical practice, Ganoderma is often used in combination with several Chinese herbs for antitumor purposes. Recent studies have revealed that the antitumor mechanism of Ganoderma mainly involves regulation of body immunity, cell cycle arrest, induction of tumor cell apoptosis and autophagy, inhibition of tumor cell metastasis, and anti-oxidation. This paper reviews the molecular mechanisms of the antitumor effects of Ganoderma, and summarizes the application and mechanisms of Ganoderma’s antitumor herbal combinations to provide a reference for the clinical application of Ganoderma.

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中央支持地方高校改革发展资金人才培养项目；黑龙江省博士后科研启动基金项目（LBH-Q20104）；2019年度哈尔滨商业大学“青年创新人才”支持计划（2019CX12）