目的 白芷药材有效成分多且复杂，单一质量标准或者单一成分控制难以有效地衡量白芷药材的质量。通过探究白芷药材有效成分比例一致性，对白芷药材的质量进行评价和控制。方法 提取78篇文献中的1297个白芷药材样本中的有效成分：欧前胡素、异欧前胡素、氧化前胡素、佛手柑内酯、水合氧化前胡素、白当归素、花椒毒酚的含量数据。对符合《中国药典》质量标准的1118个样本进行各有效成分含量比例一致性分析。结果 发现各个香豆素类有效成分与标志性成分欧前胡素含量比值在一定范围内波动，例如异欧前胡素和欧前胡素含量比值在0.08～1.08，氧化前胡素和欧前胡素含量比值在0.02～2.00，佛手柑内酯和欧前胡素含量比值0.02～0.29，含量比值在范围之外的白芷药材一般为不合格药材。然后将各个香豆素类有效成分与标志性成分欧前胡素含量比值作正态分布曲线，发现各含量比值以均数为中心呈正态分布，例如异欧前胡素和欧前胡素含量比值以0.451为中心，氧化前胡素和欧前胡素含量比值以0.719为中心，佛手柑内酯和欧前胡素含量比值以0.090 3为中心，越靠近中心则含量比值越稳定，药材质量越好。结论 单一的外观性状鉴别并不能全面反映出白芷药材质量，甚至白芷药材中的有效成分含量与按外观划分的等级相反，因此可以从有效成分的种类、组分比例和含量3个角度准确评价白芷药材质量，通过兼顾外观性状指标和化学质量指标，综合评价白芷药材的规格等级。

Objective The active ingredients of Angelica dahurica herbs are many and complex, and it is difficult to measure the quality of A. dahurica herbs effectively by a single quality standard or a single component control. This paper evaluates and controls the quality of A. dahurica herbs by exploring the consistency of the proportions of the active ingredients of A. dahurica herbs. Methods Mining the content data of 1297 A. dahurica herb samples from 78 literatures for the active ingredients: imperatorin, isoimperatorin, oxypeucedanin, bergapten, oxypeucedanin hydrate, byakangelicin, xanthotoxol. The 1118 samples that met the quality standards of the Chinese Pharmacopoeia were analyzed for the consistency of the proportion of the content of each active ingredient. Results It was found that the content ratio of each coumarin active ingredient and the iconic ingredient imperatorin fluctuated within a certain range, for example, the content ratio of isoimperatorin and imperatorin was between 0.08 and 1.08, the content ratio of oxypeucedanin to imperatorin was between 0.02 and 2.0, and the content ratio of bergapten to imperatorin was between 0.02 and 0.29. A. dahurica herbs whose content ratio was outside the range were generally unqualified herbs. Then, the ratio of the content of each coumarin active ingredient to the iconic ingredient imperatorin was drawn as a normal distribution curve. It was found that the content ratios were normally distributed with the mean as the center, for example, the content ratio of isoimperatorin and imperatorin was centered at 0.451, the content ratio of oxypeucedanin and imperatorin was centered at 0.719, and the content ratio of bergapten and imperatorin was centered at 0.0903. The closer to the center, the more stable the content ratio, and the better the quality of the herbs. Conclusion Single appearance traits identification does not fully reflect the quality of A. dahurica herbs, and even the content of active ingredients in A. dahurica herbs is opposite to the grades according to the appearance, so the quality of A. dahurica herbs can be accurately evaluated from the types of active ingredients, the proportion of components and the content of the three perspectives, and the specifications of A. dahurica herbs can be evaluated in a comprehensive manner by taking into account the indicators of the appearance traits and the indicators of the chemical quality.

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浙江省自然科学基金杰出青年基金项目（LR21H280002）；浙江省“十四五”育种专项中药材协作组项目（2021C02074）；中央本级重大增减支项目子课题（2060302）；延安大学博士启动项目（YDBK2019-64）