目的 对21世纪以来国内外黄芩Scutellaria baicalensis相关研究进展进行可视化分析，梳理其研究前沿，分析发展方向，为今后黄芩相关研究提供科学依据。方法 对Web of Science（WOS）数据库中的英文文献，中国知网、万方、维普中的中文文献进行检索并进行数据清洗。利用VOSviewer、Coocation等软件对发文量、地区/作者合作网络、关键词共现、主题演化路径进行可视化分析，并对黄芩相关的研究前沿热点进行分析。结果 纳入英文文献1560篇、中文文献22 214篇。黄芩相关领域发文量在2014年以前每年呈现上升趋势，之后每年发文量趋于稳定状态，我国在黄芩相关研究领域占主导地位。合作网络显示国际上中国与美国合作较为紧密，国内各地区合作较为散乱，协作程度较为薄弱。关键词分析表明未来黄芩的研究主要集中在代谢组学、化学成分、作用机制、抗肿瘤、阿尔茨海默症等方向。结论 黄芩相关研究进展迅速，近年来对黄芩的研究逐步稳定，2019年后有回温现象。在后续的研究过程中应注重各地区、各机构之间的合作创新。代谢组学、化学成分、作用机制、抗肿瘤、阿尔茨海默症等方向成为近年来黄芩相关领域的研究热点。黄芩不良反应机制研究还不够完善，同时在其质量评价方面需要更深一步的研究。

Objective To visually analyze the the research progress of Huangqin (Scutellaria baicalensis) at home and abroad since the 21st century, sort out the research frontiers, and analyze the development direction, so as to provide scientific basis for the future research on S. baicalensis. Methods The English literature in Web of Science (WOS) database, the Chinese literature in CNKI, Wanfang and Weipu were searched and the data were cleaned. The number of publications, regional/author cooperation network, keyword co-occurrence and topic evolution pathway were visually analyzed by VOSviewer, Coocation and other software, and the research frontier hot spots related to S. baicalensis were analyzed. Results A total of 1560 English literatures and 22 214 Chinese literatures were included in the analysis. Before 2014, the number of papers published in the fields related to S. baicalensis was on the rise every year, and after that, the number of papers published each year tended to be stable. China played a leading role in the research fields related to S. baicalensis. The cooperation network showed that the international cooperation between China and the United States was relatively close, while the domestic cooperation in various regions was scattered and weak. Keyword analysis showed that the future research on S. baicalensis would mainly focus on metabonomics, chemical composition, mechanism of action, antitumor, Alzheimer’s disease, etc. Conclusion The research on S. baicalensis had developed rapidly. In recent years, the research on S. baicalensis had gradually stabilized, and there was a warming phenomenon after 2019. In the follow-up research process, we should pay attention to the cooperation and innovation between regions and institutions. In recent years, metabonomics, chemical composition, mechanism of action, antitumor, Alzheimer’s disease and other aspects have become the research focus of S. baicalensis related fields. The mechanism of adverse reaction of S. baicalensis was not perfect, and further research was needed in its quality evaluation.

R282.71

中国工程院战略研究与咨询项目（GS2021ZDA06）；道地药材生态种植及质量保障项目（国中医药科技[2020]153号）；财政部和农业农村部：国家现代农业产业技术体系资助（CARS-21）