目的 研究山茱萸Cornus officinalis水提取物部位的化学成分。方法 采用多种色谱技术进行分离纯化，通过质谱及核磁共振等方法对化合物进行结构鉴定，并以α-葡萄糖苷酶抑制活性为指标对其降糖活性进行研究。结果 从山茱萸水提取物中分离得到了1个酚酸类化合物，鉴定为2-(2-乙氧基-2-氧乙基)-3,5-二羟基苯基4-羟基苯甲酸酯（1）；α-葡萄糖苷酶抑制活性的半数抑制浓度（median inhibition concentration，IC₅₀）值为7.439 μmol/L。结论 化合物1为新的酚酸类化合物，命名为山茱萸酸酯A，其具有较好的α-葡萄糖苷酶抑制活性。

Objective To study on the constituents from water extract of Cornus officinalis. Methods The water extract of C. officinalis was separated and purified by use of various chromatographic techniques, and the structures of the isolates were elucidated by mass spectrometry and nuclear magnetic resonance. The hypoglycemic activity of the compounds using α-glucosidase inhibitory activity as index was also investigated. Results One phenolic acid compound was isolated from the extract of C. officinalis and identified as 2-(2-ethoxy-2-oxoethyl)-3,5-dihydroxyphenyl 4-hydroxybenzoate (1). The IC₅₀value of the α-glucosidase inhibitory activity was 7.439 μmol/L. Conclusion Compound 1 is a new phenolic acid, named cornusester A, with good α-glucosidase inhibitory activity.

R284.1

中央高水平医院临床科研业务费（2023-NHLHCRF-CXYW-01，2022-NHLHCRF-YNZJ-01）；国家自然科学基金项目（82073731，82273815，82273809）；中国药学会以岭生物医药创新基金（CPA-B04-ZC-2021-005）；中国医学科学研究院基本科研业务费（2022-JKCS-1616）；天然药物活性物质与功能国家重点实验室开放基金（GTZK202101，GTZK202206）；中日友好医院菁英计划（ZRJY2021-BJ06，ZRJY2021-TD06）