骨质疏松症（osteoporosis，OP）是一种以骨密度降低、骨骼微结构改变和骨质脆弱增加为特征的骨骼疾病。由于老龄化问题的逐渐加重，OP的发病率在全球范围内迅速增加。中药在预防和治疗OP中表现出极好的前景和临床效果，然而传统动物模型具有耗时长、费用昂贵、无法准确概括骨疾病复杂性等缺点，很大程度上限制了临床前OP疾病的研究进程。而斑马鱼模型可有效模拟人类骨质减少和OP表型，通过对斑马鱼模型在治疗OP研究中的优势和适用性及该模型在中药抗OP的研究进展进行综述，为斑马鱼模型的广泛使用及中药新药研发提供参考。

Osteoporosis is a bone disease characterized by decreased bone density, changes in bone microstructure, and increased bone fragility. Due to the increasing aging problem, the incidence of osteoporosis is increasing rapidly around the world. Traditional Chinese medicine has shown excellent prospects and clinical effects in the prevention and treatment of osteoporosis. However, traditional animal models have disadvantages of time-consuming, high cost and inability to accurately summarize the complexity of bone diseases, which greatly limits the research process of preclinical osteoporosis diseases. The zebrafish model can effectively simulate the human osteopenia and osteoporosis phenotype. The advantages and applicability of zebrafish model in the treatment of osteoporosis and the research progress of this model in the anti-osteoporosis of Chinese medicine were reviewed, with view to providing references for the widespread use of zebrafish model and the development of new Chinese medicine drugs.

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国家自然科学基金资助项目（82204753）；国家科技重大专项（2018ZX09735005）；国家中医药管理局公益性中医药行业科研专项（201507004）