抑郁症是慢性躯体疾病最常见的共病之一，躯体疾病共病抑郁（physical disease comorbid with depression，PDCD）对病程和预后有不利影响。葛根Puerariae Lobatae Radix具有解肌退热、生津止渴、透疹、升阳止泻、通经活络、解酒毒等功效，在多种PDCD中应用广泛。通过查阅近年来国内外以葛根单味药及含葛根的中药复方治疗或干预PDCD的研究文献，对葛根在PDCD中的应用及其作用机制进行综述，解析葛根治疗PDCD的应用价值，并对其干预抑郁症和PDCD的作用机制进行对比分析，为葛根治疗PDCD的临床应用提供理论依据。

Depression is one of the most common comorbidities of chronic physical diseases. Physical disease comorbid with depression (PDCD) have adverse effects on the course and prognosis of diseases. Gegen (Puerariae Lobatae Radix) has the functions of relieving muscle and fever, promoting body fluid and quenching thirst, clearing rash, raising yang and preventing diarrhea, promoting meridians and activating collaterals, and relieving alcohol poisoning. Puerariae Lobatae Radix is widely used in various PDCD. The research literature on the application of Puerariae Lobatae Radix and Puerariae Lobatae Radix-contained traditional Chinese medicine (TCM) formulae in the treatment and/or intervention of PDCD was searched and analyzed in order to review the the application and mechanism of Puerariae Lobatae Radix in the treatment of PDCD. We also explored the application value of Puerariae Lobatae Radix on PDCD, compared the difference of antidepressant mechanism of Puerariae Lobatae Radix on depression and PDCD, so as to provide theoretical basis for the clinical application of Puerariae Lobatae Radix in the treatment of PDCD.

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国家自然科学基金资助项目（81903824）；济宁医学院高层次科研项目培育计划（JYGC2021KJ004）