肉豆蔻Myristicae Semen是常用药食同源中药，具有温中行气、涩肠止泻的功效，主要包括木脂素类、挥发油类和多酚类等化学成分，具有调节消化系统、抗癌、抗炎镇痛、抗菌、抗氧化等药理作用。通过对肉豆蔻化学成分、药理作用、毒性和临床应用进行综述，根据中药质量标志物（quality marker，Q-Marker）理念，从植物亲缘、采收时期和炮制方法、药效、药性、配伍、化学成分可测性等方面对肉豆蔻的Q-Marker进行预测分析，初步预测去氢二异丁香酚、肉豆蔻醚、安五脂素、甲氧基丁香酚、榄香素、丁香酚和α-蒎烯等为其可能的Q-Marker，为肉豆蔻质量评价和药品研发提供参考。

Roudoukou (Myristicae Semen) is a commonly used medicine and food homologous traditional Chinese medicine, which has the effects of warming the middle and moving qi, astringing the intestines and checking diarrhea. Its chemical components mainly include lignans, volatile oils and polyphenols. Myristicae Semen has the pharmacological effects of regulating the digestive system, anti-cancer, anti-inflammatory and analgesic, antibacterial and antioxidant, etc. This paper reviews its chemical constituents, pharmacological effects, toxicity studies and clinical applications. According to the concept of quality marker (Q-Marker) of traditional Chinese medicine, Q-Markers of Myristicae Semen was predicted from plant affinity, collecting periods and processing methods, efficacy, medicinal properties, compatibility, and chemical component measurability. It was preliminarily predicted that dehydrodiisoeugenol, myristicin, macelignan, methoxyeugenol, elementin, eugenol and α-pinene were the possible Q-Marker, to provid a reference for the quality evaluation and drug development of Myristicae Semen.

R285

中央引导地方科技发展专项：二十味肉豆蔻丸品质提升及二次开发研究（YDZX2021083-04）