高血压是临床最常见的慢性疾病之一。西医治疗高血压以血管紧张素转换酶抑制剂、钙离子通道阻滞剂、β-受体阻滞剂和利尿剂为主导。与西药相比，中药具有多成分、多靶点、整体调节的优势，且安全性高。近年来，钩藤及其制剂在治疗心血管疾病尤其是高血压病上取得了较好的疗效。钩藤主要从抑制交感神经系统活性、阻断肾素-血管紧张素-醛固酮系统、改善内皮功能、发挥钙拮抗剂作用等方面产生降压作用。结合文献报道，从钩藤单体化学成分、钩藤提取物、钩藤配伍制剂3个方面总结钩藤及其制剂在治疗高血压病中的应用，以期为钩藤治疗高血压病的临床应用提供更全面的数据基础。

Hypertension is one of the most common chronic diseases in clinic. Western medicine treats hypertension dominated by angiotensin converting enzyme inhibitors, calcium channe blockers, β-receptor blockers and diuretics. Compared with western medicine, traditional Chinese medicine has the advantages of multi-component, multi-target and overall regulation, with high safety. In recent years, Uncariae Ramulus Cum Uncis and its preparations have achieved good efficacy in the treatment of cardiovascular diseases, especially hypertension. Uncariae Ramulus Cum Uncis presents hypotensive effect by inhibiting sympathetic nervous system activity, blocking renin-angiotensin-aldosterone system, improving endothelial function and playing the role of calcium antagonist. Combined with literature reports, the application of Uncariae Ramulus Cum Uncis and its preparations in the treatment of hypertension was summarized from three aspects of chemical components of monomer, extract and compatible preparations, in order to provide a more comprehensive data basis for the clinical application of Uncariae Ramulus Cum Uncis in the treatment of hypertension.

天津市教委科研计划“基于miRNA的天麻钩藤饮干预高血压前期大鼠炎性因子及内皮损伤的研究”（2018KJ033）