中药化学成分组成是其物质基础，针对中药中有效成分、特征成分及有害物质的定性、定量分析，是阐明中药药效成分和鉴定其品质的主要方式。实时直接分析质谱（direct analysis in real time-mass spectrometry，DART-MS）技术无需或仅需简单的样品处理，具有快速、直接、现场检测等特点，将其引入到中药质量研究，有助于评价中药质量的稳定性和安全性。通过对DART-MS离子源结构、原理及在中药质量研究中的应用进行综述，为该技术在中药领域的应用提供参考。

The properties of traditional Chinese medicine are determined by its chemical composition. Qualitative and quantitative analysis based on effective, characteristic and harmful components has been commonly used for accessing medicinal ingredients and evaluating the quality of traditional Chinese medicine. Direct analysis in real time-mass spectrometry (DART-MS) technique allows rapid, direct and on-site detection with minimal-to-no sample preparation. Thus, the introduction of which is conductive to evaluation of the stability and security for the quality of traditional Chinese medicine. The technique needs no or only simple sample treatment, and has the characteristics of fast, direct and on-site detection. The application of DART-MS technology in the quality research of traditional Chinese medicine was reviewed to provide reference for the application of this technology in the field of traditional Chinese medicine.

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“十四五”广东省农业科技创新十大主攻方向“揭榜挂帅”项目（2022SDZG07）