瘢痕是各种创伤所引起的正常皮肤组织外观形态和组织病理变化的总称，严重影响患者的容貌，且易引起肢体功能障碍和不适等。细胞亲和性是药物制剂能否在疾病部位稳定释放并充分发挥疗效的主要影响因素。伤口愈合过程的复杂性导致瘢痕的形成受到多种因素的影响，基于细胞亲和性能设计瘢痕治疗的纳米靶向经皮给药制剂，可有效提高治愈率。通过对细胞亲和性设计的防治瘢痕纳米靶向经皮制剂进行综述，为更多瘢痕防治策略的开发与临床应用提供参考。

Scar is a general term for the appearance, morphology, and histopathological changes of normal skin tissue caused by various types of trauma, which seriously affects the appearance of patients and can easily cause limb dysfunction and discomfort. Cell affinity is the main influencing factor for the stable release and full efficacy of drug formulations at disease sites. The complexity of wound healing process leads to the formation of scars being influenced by various factors. The design of nano targeted percutaneous drug delivery formulations for scar treatment based on cell affinity performance can effectively improve the healing rate. This review provides a reference for the development and clinical application of scar prevention and treatment strategies through the review of cell affinity designed nano-transdermal formulations for scar prevention and treatment.

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国家自然科学基金资助项目（82173982）；广东省自然科学基金资助项目（2022A1515011382）