肿瘤微环境（tumor microenvironment，TME）在肿瘤的发生、发展、转移等环节起到至关重要的作用。中药多糖抗肿瘤作用显著，具有多角度、多机制协同作用的特点，可避免产生耐药性，是具有极大研究价值和开发潜力的抗肿瘤天然药物新领域。通过对TME中的免疫细胞（肿瘤相关巨噬细胞、树突状细胞、髓源性抑制细胞、肿瘤浸润性淋巴细胞、肿瘤相关中性粒细胞）进行综述，系统地阐述了各免疫细胞的生物学特性及中药多糖对其调控作用的研究进展，为抗肿瘤中药的研发提供参考。

Tumor microenvironment (TME) plays an important role in the occurrence, development and metastasis of tumors. Traditional Chinese medicine (TCM) polysaccharide has obvious anti-tumor effect with multi-angle and multi-mechanism synergy, and can avoid drug resistance, which is a new field of antitumor drugs with great research value and development potential. This paper reviewed the immune cells in TME (tumor-associated macrophages, dendritic cells, myeloid-derived suppressor cells, tumor infiltrating lymphocytes, tumor-associated neutrophils), the biological properties of each immune cell and the research progress of the regulatory effects of TCM polysaccharides on them were systematically described to provide reference for the research and development of antitumor TCM.

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黑龙江省重点研发计划指导类项目（GZ20210088）；黑龙江省中医药管理局科技计划项目（ZHY2020-175）；哈尔滨商业大学产业化项目（22CZ13）