[关键词]
[摘要]
药用植物细胞外囊泡(medicinal plant-derived extracellular vesicles,MPEVs)是由其药用植物特定部位细胞分泌的,装载有小分子化合物、核酸、蛋白质和脂质等功能物质的纳米级膜囊泡。由于具有其同源植物中的活性物质,MPEVs具有特殊的生物活性。通过对近年来MPEVs的分离纯化、鉴定、成分分析、生物活性等方面进行总结分析,为作为新型药效物质的深入研究提供借鉴和启示。
[Key word]
[Abstract]
Medicinal plant-derived extracellular vesicles (MPEVs) are nanoscale membrane vesicles loaded with functional substances such as small molecules, nucleic acids, proteins and lipids secreted by cells in particular parts of medicinal plants. Due to the presence of active substances from their homologous plants, MPEVs possess unique biological activity. As a result, the isolation and purification, identification, compositional analysis, and biological activity of MPEVs in recent years are summarized and analyzed in this review to provide reference and insight for in-depth research of MPEVs as novel pharmacological substances.
[中图分类号]
R283;R285
[基金项目]
中央本级重大增减支项目(2060302-1907-09);山东第一医科大学学术提升计划(2019LJ003)