细辛Asari Radix et Rhizoma首载于《神农本草经》，具有解表散寒、祛风止痛、通窍、温肺化饮的功效，主要化学成分包括木脂素类、挥发油类、酸类、苷类、含氮化合物等。现代药理学研究表明，细辛具有抗炎镇痛、止咳平喘、抗菌、抗病毒等多种药理作用。通过对近10年细辛的化学成分、药理作用、临床应用和安全性进行综述，从植物亲缘、药效、药性、配伍、化学成分可测性等方面预测分析细辛质量标志物（quality marker，Q-Marker），初步预测细辛脂素、芝麻脂素、甲基丁香酚、β-细辛醚、阿魏酸、十二碳四烯酰胺A和十二碳四烯酰胺B等可作为其Q-Marker，为建立和完善细辛质量评价体系提供参考。

Xixin (Asari Radix et Rhizoma) was first recorded in Shennong’s Classic of Materia Medica. It has the effects of relieving exterior and dispersing cold, dispelling wind and relieving pain, opening orifices, and warming lungs and resolving fluid retention. The main chemical components include lignans, volatile oils, acids, glycosides, nitrogen compounds, etc. Modern pharmacology indicates that Asari Radix et Rhizoma has various pharmacological effects such as anti-inflammatory and analgesic, cough relieving and asthma relieving, antibacterial, and antiviral. Through a review of the chemical composition, pharmacological effects, clinical applications, and safety of Asari Radix et Rhizoma in the past decade, quality marker (Q-marker) prediction analysis was conducted on Asari Radix et Rhizoma from aspects of plant affinity, efficacy, pharmacological properties, compatibility, and chemical component testability. Asarinin, sesamin, methyl eugenol, β-asarone, ferulic acid, dodecatetraenamide A, and dodecatetraenamide B can be used as its Q-Marker through the preliminary predictions, with view to providing reference for the establishment and improvement of quality evaluation system of Asari Radix et Rhizoma.

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山东省重点研发计划项目（2020CXGC010505-06）；山东省高校青年创新团队（人才引育计划）