目的 通过文献计量学软件CiteSpace对石榴皮的研究现状及热点进行可视化分析，为国内突破石榴皮研究瓶颈和发现研究新思路提供参考。方法 基于中国知网数据库和Web of Science数据库进行文献检索，时间限定为2002年1月1日—2022年11月20日，共纳入3447篇符合标准的文献，对年发文量，国家（地区）、机构、作者合作网络，关键词共现、聚类、突现词，英文文献共被引进行分析。结果 石榴皮研究中文文献发文量增长平缓，英文文献发文量增长快速，国内外对于石榴皮研究的热度不同。发文最多的3个国家是印度、中国、伊朗，国内主要的研究机构有新疆医科大学、陕西师范大学、武汉大学、武汉大学人民医院，国外主要的研究机构有伊斯兰阿扎德大学（Islamic Azad University）、沙特阿拉伯国王大学（King Saud University）等。国内外主要的核心作者有周文宏、高晓黎、Opara Umezuruike Linus等。国内研究内容主要集中于化学成分和药理作用方面，国外主要研究集中于石榴皮作为食品添加剂方面。结论 抑菌、抗动脉粥样硬化、治疗结肠炎、抗肿瘤等药理作用机制的研究以及安石榴苷、鞣花酸等化学成分的提取和纯化是国内研究需要突破的瓶颈。作为食品添加剂的口感优化和毒理学研究以及纺织物染色的应用是今后石榴皮研究的新方向。

Objective The research status and hotspots of Shiliupi (Granati Pericarpium, pomegranate peel) were analyzed visually through the bibliometric software CiteSpace, so as to provide reference for breaking through the bottleneck of Granati Pericarpium research and finding new research ideas in China. Methods Literature retrieval was conducted based on CNKI database and Web of Science database, and the time was limited to January 1, 2002 to November 20, 2022. A total of 3447 literatures that met the criteria were included. The annual number of published papers, countries (regions), institutions, author cooperation network, keyword co-occurrence, clustering, emergent words, and co-citation of English literature were analyzed. Results The number of Chinese articles on Granati Pericarpium research was increased slowly, while the number of English articles was increased rapidly. The popularity of Granati Pericarpium research at home and abroad was different. The top three countries with the most publications were India, China and Iran. The main research institutions at home and abroad included Xinjiang Medical University, Shaanxi Normal University, Wuhan University, Renmin Hospital of Wuhan University, Islamic Azad University, King Saud University, etc. The main core authors at home and abroad include Zhou Wen-hong, Gao Xiao-li, Opara Umezuruike Linus, etc. The main research content in China was chemical composition and pharmacological effect, and the main research in foreign countries was Granati Pericarpium as food additive. Conclusion The bottleneck of domestic research needs to be broken through was the research on the pharmacological mechanisms of antibacterial, anti-atherosclerosis, colitis treatment, and antitumor, as well as the extraction and purification of the chemical components such as anpomegranin and ellagic acid. The new directions of research were taste optimization and toxicology of pomegranate peel as a food additive, as well as textile dyeing application.

R284；R285

国家自然科学基金项目（82174209）