地黄多糖是地黄Rehmannia glutinosa的主要活性成分之一，主要由葡萄糖、鼠李糖、甘露糖等单糖组成。地黄多糖的提取方法有很多种，不同的提取方法具有其独特的优势并且影响了地黄多糖的得率。纯化是获取地黄多糖不可或缺的步骤，经过除蛋白、色素等操作，可以保证地黄多糖的纯度，使其后续研究更加准确。地黄多糖及其衍生物具有免疫调节、神经调节、抗氧化、抗炎、抗肿瘤、治疗糖尿病等多种药理功能，具有潜在的药用价值。综述了地黄多糖的提取纯化方法、药理活性和载体新剂型等方面的研究进展，为地黄多糖及其衍生物的进一步研究提供了基础。

Rehmannia glutinosa polysaccharide (RGP) is one of the main active ingredients of traditional Chinese medicine Dihuang (Rehmanniae Radix), mainly composed of glucose, rhamnose, mannose and other monosaccharides. There are many extraction methods of RGP. Different extraction methods have their unique advantages and affect the yield of RGP. Purification is an indispensable step to obtain RGP. After removing protein, pigment and other operations, the purity of RGP can be guaranteed, making its follow-up study more accurate. RGP and its derivatives have a variety of pharmacological functions such as immune regulation, neuromodulation, antioxidant, anti-inflammatory, anti-tumor, and treatment of diabetes, and have potential medicinal value. In this paper, the research progress of extraction and purification methods, pharmacological activities and carrier application of RGP were reviewed, which provided a basis for further research of RGP and its derivatives.

中央引导地方科技发展资金项目（YDZX2021050）