溃疡性结肠炎（ulcerative colitis，UC）是一种慢性、易复发性和使人衰弱的、多因素导致的复杂炎症性疾病，其发病具体原因尚不清楚，目前治疗UC的药物主要包含合成药物和单克隆抗体，然而长期使用这些药物可能会产生严重的不良反应。姜黄素是从姜科植物中提取的天然活性成分，具有显著的抗炎作用，可能与多种炎症细胞通路靶点相互作用有关，是治疗UC的候选药物。通过对近年来姜黄素治疗UC的机制及其微纳米传递系统抗UC研究进行归纳，并进一步讨论姜黄素抗炎制剂的开发与临床应用存在的局限性和可能的解决方法，为姜黄素在UC防治中的深入研究及其制剂开发应用提供一定的思路。

Ulcerative colitis (UC) is a chronic, recurrent and debilitating, multifactorial complex inflammatory disease, the specific cause of which is not clear, the current treatment of UC drugs mainly include synthetic drugs and monoclonal antibodies, but long-term use of these drugs may produce serious adverse reactions. Curcumin is a natural active ingredient extracted from Zingiberaceae family. A large number of in vivo and in vitro researches have suggested that curcumin, which may be related to multiple inflammatory cell pathway and target interactions, has significant anti-inflammatory effects, so it is the drug candidate for treatment of UC. This article summarizes the mechanism of curcumin’s treatment of UC and its micro-nano delivery system anti-UC research, and further discusses the limitations and possible solutions in development and clinical application of curcumin. In order to provide certain ideas for the in-depth research of curcumin in prevention and treatment of UC and development and application of its preparations.

江西中医药大学中药制剂技术与装备创新团队（CXTD22006）；江西中医药大学校级创新创业训练计划（x202310412247）