[关键词]
[摘要]
炎症性肠病(inflammatory bowel disease,IBD)是原因尚不明确的非特异性的肠道炎症性疾病。遗传、环境因素、免疫功能障碍、肠道菌群失调及肠道屏障功能受损都是其发生和发展的主要原因。临床上常用的治疗药物有氨基水杨酸类、抗生素类、皮质类固醇类等,但治愈率较低且不良反应明显。研究表明,中药天然产物具有免疫调节、调节肠道菌群组成和改善肠黏膜屏障功能等作用,可以有效治疗IBD。通过对常见的中药天然产物治疗IBD的研究进展进行综述,为中药天然产物的进一步开发及IBD的治疗提供一定的理论指导。
[Key word]
[Abstract]
Inflammatory bowel disease (IBD) is a non-specific intestinal inflammatory disease with unclear causes. It is thought that genetic elements, environmental elements, immune dysfunction, imbalance of intestinal flora and impairment of intestinal mucosal barrier function are the primary causes for the occurrence and development of IBD. The frequently used therapeutic drugs in clinic contain aminosalicylic acids (ASA), antibiotics and corticosteroids, yet the curative ratio is inferior and the side effects are obvious. New research suggests that the active constituents of traditional Chinese medicine (TCM) have the impact on such as adjusting immune function, ameliorating the composition of intestinal flora and promoting the function of intestinal mucosal barrier. Therefore, it can be used to treat IBD effectively. This article summarizes application and research advance about common natural products extracted from TCM in the treatment or prevention of IBD, mainly containing alkaloids, polyphenols, flavonoids, terpenoids, quinones, saponins and polysaccharides, which may contribute to comprehending more about their action mechanism for natural products of TCM in improving IBD, offering some theoretical guidance for the further development of natural products of TCM and the therapy of IBD.
[中图分类号]
R285
[基金项目]
国家自然科学基金资助项目(61671098);韩国食品研究项目(2017029)