藤黄是藤黄科植物藤黄Garcinia hanburyi所分泌的干燥树脂，其化学成分多样，主要包括笼状呫吨酮、五环三萜和植物甾醇，具有抗肿瘤、抗炎、抗菌等药理作用。近年来，研究发现藤黄在抗癌方面有着十分显著的疗效。基于藤黄化学成分和药理作用的研究进展，并根据中药质量标志物理论，从植物亲缘学、化学成分可测性、化学成分有效性、制剂因素的角度进行质量标志物初步预测分析，表明藤黄酸和新藤黄酸可作为藤黄的主要质量标志物，为藤黄质量控制和研究开发提供参考依据。

Gamboge is a dry resin secreted by Garcinia hanburyi of Guttiferae family, which has a variety of chemical compositions, mainly including caged xanthone, pentacyclic triterpenoids and phytosterols. It has antitumor, anti-inflammatory, antibacterial and other pharmacological effects. In recent years, studies have found that Gamboge has a very significant effect in anticancer. Based on the research progress of the chemical constituents and pharmacological effects of Gamboge, and according to the theory of quality markers of traditional Chinese medicine, this paper presents a preliminary prediction analysis of its quality markers from the perspectives of plant affinities, chemical composition measurability, chemical composition effectiveness and formulation factors. It was found that gambogic acid and gambogenic acid can be used as the main quality markers of Gamboge, which provide a reference basis for quality control and research development of Gamboge.

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国家自然科学基金面上项目（81773988）