脓毒症被定义为由宿主对感染反应失调引起的危及生命的器官功能障碍，是全世界重症监护病房患者的主要死因。在脓毒症中自噬作为细胞适应性调节机制，对于机体免疫、呼吸、循环及凝血等系统具有保护作用。多项研究发现中药可通过多途径、多靶点调节细胞自噬，抑制细胞凋亡，减轻炎症反应与器官损伤，从而有效防治脓毒症。基于相关研究，综述了中药通过干预自噬相关通路和靶点防治脓毒症的研究进展，为中药治疗脓毒症提供依据。

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the leading cause of death in intensive care units worldwide. Autophagy, as a cellular adaptive regulatory mechanism in sepsis, plays a protective role in the immune, respiratory, circulatory, and coagulation systems. A number of studies have demonstrated that traditional Chinese medicine (TCM) can regulate autophagy, inhibit apoptosis, reduce inflammation and organ damage through multiple pathways and targets, and achieve the purpose of effective prevention and treatment of sepsis. Based on relevant studies, this article summarizes the progress of TCM which intervenes in sepsis by regulating autophagy pathways and targets, providing evidence for the treatment of sepsis with TCM.

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国家自然科学基金面上项目（81973581）；天津市科学技术局项目（20ZYJDJC00070）