目的 基于文献挖掘探讨中药减轻雷公藤雌性生殖毒性的规律分析，为临床合理用药、规避药物不良反应提供参考。方法 以“雷公藤、中草药、生殖”为主题，检索自1981年1月1日—2022年8月31日中国知网、万方、维普、中国生物医学文献数据库及PubMed、Cochrane Library、Embase数据库中相关研究文献，建立数据库，人工筛选文献，用Excel 2021数据透视表统计中药的药味、药性、归经和功效分类，用SPSS Modeler 18.0及SPSS Statistics 26.0软件进行可视化分析。结果 归纳总结符合纳入标准的43篇文献，共涉及84味减轻雷公藤雌性生殖毒性的中药，使用频率≥1%的有熟地黄、菟丝子、当归、枸杞子等28味中药，性味归经以甘、辛、苦3味，温、平、微温3性，肝、肾、脾3经占据前3，补阳药占21.88%，补血药占16.96%，补阴药占12.50%，补气药占10.49%，活血调经药占9.15%。药物关联分析得出21个常用药物组合。对频率≥1%的28味中药进行聚类分析，得出7个新处方。结论 雷公藤雌性生殖毒性的减毒用药规律中，熟地黄-菟丝子是高频药物中最常用的制约雷公藤雌性生殖毒性的药对。

Objective To explore the regularity of traditional Chinese medicine (TCM) for attenuating the female reproductive toxicity of Leigongteng (Tripterygium wilfordii Hook. f.) based on literature mining, providing reference for clinical rational drug use and avoidance of adverse drug reactions. Methods The relevant research literatures in CNKI, Wanfang, VIP, China Biomedical Literature Database and PubMed, Cochrane Library and Embase databases were searched from January 1, 1981 to August 31, 2022, with the theme of “Tripterygium wilfordii, Chinese herbal medicine and reproduction”. The database was established and literatures was manually screened. The classification of flavor, property, meridian tropism and efficacy of TCM were analyzed by Excel 2021. The data were visualized by SPSS Modeler 18.0 and SPSS Statistics 26.0. Results A total of 43 articles were summarized, 84 kinds of TCMs for attenuating the female reproductive toxicity of T. wilfordii were involved. 28 kinds of TCMs, such as Shudihuang (Rehmanniae Radix Praeparata), Tusizi (Cuscutae Semen), Danggui (Angelicae Sinensis Radix) and Gouqizi (Lycii Fructus), were used more than 1%. The property, flavors and meridian tropism were composed of sweet, pungent and bitter flavors, and warm, flat and mild natures, liver, kidney and spleen meridians occupy the top three. The yang-reinforcing drugs accounted for 21.88%, the blood-reinforcing drugs accounted for 16.96%, the yin-reinforcing drugs accounted for 12.50%, the qi-reinforcing drugs accounted for 10.49%, promoting blood circulation and regulating menstruation drugs accounted for 9.15%. Drug association analysis showed 21 common drug combinations. Cluster analysis was carried out on 28 kinds of TCMs with frequency ≥ 1%, and seven new prescriptions were obtained. Conclusion Rehmanniae Radix Praeparata and Cuscutae Semen are the most commonly used drug pair in the high-frequency medicine to restrict the female reproductive toxicity of T. wilfordii.

R285;R283.21

国家自然科学基金青年基金面上项目（82205187）；中国博士后科学基金项目（2021M690940）；中国民族医药学会科研项目（2021 Z1182-400614）；河南省中医药科学研究专项（20-21ZY2031）；河南省特色骨干学科中医药学科建设项目（STG-ZYXKY-2002030）；河南中医药大学科研启动基金（RSBSJJ2019-23）；河南中医药大学研究生科研创新项目（2021KYCX047）