松果菊苷是从肉苁蓉Cistanches Herba、玄参Scrophulariae Radix、地黄Rehmanniae Radix等中药中提取的一种苯乙醇苷类化合物，也是肉苁蓉的关键质量指标成分，具有显著的抗炎、抗氧化、神经保护等药理活性。松果菊苷对于神经系统疾病的治疗价值已得到众多基础研究的证实，临床运用潜力巨大。通过对松果菊苷治疗帕金森病、阿尔茨海默病、认知障碍、血管性痴呆等神经系统疾病的药理作用进行归纳，总结其治疗神经系统疾病的可能作用机制，以期为深入探索松果菊苷的后续研究提供参考，为神经系统疾病治疗药物的开发提供理论依据。

Echinacoside is a phenylethanol glycoside from Cistanches Herba, Scrophulariae Radix, and Rehmanniae Radix, which is also a key indicator component of Cistanches Herba. The therapeutic potential of echinacoside for neurological diseases has been confirmed by numerous studies due to its extensive anti-inflammatory, antioxidant, and neuroprotective activities. In this paper, the pharmacological effects of echinacoside in treatment of Parkinson’s disease, Alzheimer’s disease, cognitive impairment, vascular dementia, and other neurological diseases were systematically reviewed, and the mechanisms of echinacoside in treating neurological diseases were summarized as much as possible, which hoping to provide a reference for the in-depth exploration of echinacoside and a theoretical basis for the development of therapeutic drugs for neurological diseases.

R285

四川省中药管理局资助项目（2012-E-048）；四川省教育厅资助项目自然科学重点（14ZA0080）