槲皮素是蔬菜、水果、中药中常见的黄酮类化合物，是天然的抗氧化剂，具有抗癌、抗糖尿病、抗菌、抗炎、抗病毒等生物活性。由于槲皮素生物利用度低，限制了其在临床上的应用。通过各种方法设计和合成新的槲皮素衍生物，以改善其缺点，进而发挥预防和治疗疾病的作用。通过对槲皮素衍生物的合成及其抗癌、抗糖尿病、抗炎、抗菌和抗病毒活性进行综述，并对其构效关系进行分析，为天然化合物的开发和利用奠定基础。

Quercetin is a common flavonoid found in vegetables, fruits and traditional Chinese medicine. It is a natural antioxidant with anti-cancer, anti-diabetes, antibacterial, anti-inflammatory, anti-virus and other biological activities. The low bioavailability of quercetin limits its clinical application. New quercetin derivatives were designed and synthesized by various methods to improve their shortcomings and thus play a role in the prevention and treatment of diseases. By reviewing the synthesis and anti-cancer, anti-diabetes, anti-inflammatory, antibacterial and antiviral activities of quercetin derivatives, and analyzing their structure-activity relationship, we lay a foundation for the development and utilization of natural compounds.

R282.710.85

郑州市高等学校名师技术技能工作室（郑教高[2015]70号）；教育部产学研协同育人项目（202102028026）