“肠-肝”轴相关疾病是一类基于肝脏和肠道相互作用失衡而引起或加重的疾病。传统中医学基于五脏整体观对“肠-肝”轴相关疾病的认知延伸了自身的肝脾概念，调和肝脾类中药对“肠-肝”轴相关疾病亦有积极的治疗效果，契合中医“肝脾同调，治肝实脾”的独特理念。通过对调和肝脾类中药调节肠道微生态及免疫微环境、保护肠道机械屏障、平衡胆汁酸稳态、调节神经递质治疗“肠-肝”轴相关疾病进行系统性回顾，为从“肠-肝”轴角度阐释调和肝脾类中药的现代科学内涵提供新的思路，助力创新中药开发。

“Gut-liver” axis related diseases are induced and exacerbated by unbalanced interaction between liver and intestine. The unique cognition of “gut-liver” axis diseases, which is based on the “holism of five organs” theory, extended the concept of liver and spleen in traditional Chinese medicine, with the effective therapies of harmonizing the liver and spleen and correlative representative prescriptions in clinical, which also tallied with the consensus of “harmonizing the liver and spleen, curing the liver to reinforcing spleen” in traditional Chinese medicine. Therefore, the review aims to offer an innovative therapeutic perspective for the “gut-liver” axis diseases and help the creative exploitation of traditional Chinese medicine by elaborating the scientific connotation of prescriptions and herbs that harmonize the liver and spleen, which through adjusting the intestinal microecology and immune microenvironment, protecting the intestinal mechanical barrier, maintaining the bile acid homeostasis and regulating the neurotransmitter.

R285

国家自然科学基金资助项目（82004029）；中华中医药学会青年人才托举工程项目（2020-QNRC2-01）