[关键词]
[摘要]
目的 观察腰痛宁胶囊联合布洛芬缓释胶囊治疗腰椎间盘突出症的临床疗效。方法 选择2020年1月—2021年12月在唐山市工人医院进行腰椎间盘突出症治疗的110例患者,按随机数表法将患者分为对照组和治疗组,每组各55例。对照组采用布洛芬缓释胶囊进行治疗,治疗组采用腰痛宁胶囊联合布洛芬缓释胶囊进行治疗。对比两组患者临床疗效、日本骨科协会评估治疗(Japanese Orthopaedic Association,JOA)评分、腰椎活动度、血液流变学指标、血清前列腺素E2(prostaglandin E2,PGE2)水平及视觉模拟评分(visual analogue scale,VAS)的变化。结果 治疗后,治疗组总有效率为98.15%,显著高于对照组的86.79%,两组比较差异显著(P<0.05)。治疗后两组血液流变学指标全血还原黏度(whole blood reduced viscosity,WBRV)、血浆黏度(plasma viscosity,PV)、纤维蛋白原(fibrinogen,FIB),血清PGE2水平、VAS评分均较治疗前显著降低(P<0.05),且治疗组患者治疗后血液流变学指标、血清PGE2水平及VAS评分水平均显著低于对照组(P<0.05)。治疗后两组JOA评分及腰椎活动度均较治疗前显著提高(P<0.05),且治疗组患者治疗后JOA评分及腰椎活动度显著高于对照组(P<0.05)。两组患者基本无不良反应发生。结论 腰痛宁胶囊联合布洛芬缓释胶囊治疗腰椎间盘突出症患者疗效显著,同时可改善患者血液流变学指标及PGE2水平,缓解疼痛并提高腰椎活动度。
[Key word]
[Abstract]
Objective To observe the clinical effect of Yaotongning Capsules (腰痛宁胶囊) combined with Ibuprofen Sustained-Release Capsules (布洛芬缓释胶囊) in treatment of lumbar disc herniation.Methods A total of 110 patients with lumbar disc herniation treated in Tangshan Workers’ Hospital from January 2020 to December 2021 were selected. According to the random number table method, the patients were divided into the control group and treatment group, with 55 cases in each group. The control group was treated with Ibuprofen Sustained-Release Capsules, and the treatment group was treated with Yaotongning Capsules combined with Ibuprofen Sustained-Release Capsules. The clinical efficacy, Japanese Orthopaedic Association (JOA) score, lumbar range of motion, hemorheology index, serum prostaglandin E2(PGE2) level and visual analogue scale (VAS) score were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 98.15%, which was significantly higher than that of the control group (86.79%), and the difference between the two groups was significant (P < 0.05). After treatment, the whole blood reduced viscosity (WBRV), plasma viscosity (PV), fibrinogen (FIB), serum PGE2 and VAS scores of the two groups were significantly lower than those before treatment (P < 0.05), and the hemorheology index, serum PGE2 level and VAS scores of the treatment group were significantly lower than those of the control group after treatment (P < 0.05). After treatment, the JOA score and lumbar range of motion in the two groups were significantly higher than those before treatment, and the JOA score and lumbar range of motion in the treatment group were significantly higher than those in the control group (P < 0.05). No adverse reactions occurred in the two groups. Conclusion Yaotongning Capsules combined with Ibuprofen Sustained-Release Capsules has a significant effect on patients with lumbar disc herniation, and can improve the hemorheology index and PGE2 level, relieve pain and improve lumbar motion.
[中图分类号]
R285.64
[基金项目]
河北省中医药管理局科研计划项目(2020428)