随着生活水平的不断提高，高脂、高蛋白饮食导致癌症、心脑血管疾病、过敏性疾病已成为威胁人类健康的主要病因，其中抗氧化、清除自由基是重要的预防和治疗方式之一。二咖啡酰奎宁酸类化合物在自然界分布广泛，具有多酚羟基结构，生理活性多样，包括抗氧化、抗炎、降血糖、调血脂、抑制血小板、抗微生物、抗肿瘤等，引起国内外众多学者的广泛关注。由于理化性质及药动学影响，其药物开发并不完善。通过对二咖啡酰奎宁酸类化合物的植物来源、药动学以及生物活性研究进展进行综述，以期为其开发利用提供依据。

With the continuous improvement of the living standard, high-fat and high-protein diet leading to cancer, cardiovascular and cerebrovascular diseases, and allergic diseases have become the main causes of threats to human health, of which antioxidant and free radical scavenging is one of the important prevention and treatment methods. Dicaffeoylquinic acids are widely distributed in nature, with polyphenol structure and various physiological functions including antioxidant, anti-inflammatory, hypoglycemic, lipid-lowering, platelet inhibitory, antimicrobial and anti-tumor, etc., which have attracted extensive attention from many scholars at home and abroad. Due to the influence of physicochemical properties and pharmacokinetics, its drug development is not perfect. In this paper, the plant origins, pharmacokinetics, and biological activities of natural dicaffeoylquinic acids were reviewed to provide basis for their development and utilization.

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国家自然科学基金地区基金项目（82260822）；中央引导地方科技发展资金项目（2020ZY0036）；中国科学院“西部之光”青年学者资助项目（人字[2020]82号）；内蒙古自治区自然科学基金面上项目（2022MS08034）；内蒙古自治区卫生健康委员会医疗卫生科技计划项目（202202379）；鄂尔多斯市科技计划项目（鄂财教指[2019]501号）