目的 综合评价口服含柴胡制剂治疗抑郁症、上呼吸道感染、功能性消化不良的有效性及安全性。方法 计算机检索中国学术期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang Date)、美国生物医学期刊文献数据库(PubMed)、Web of Science和Cochrane Library等数据库中从建库至2022年7月份的临床运用含柴胡制剂、方剂治疗抑郁症、上呼吸道感染、功能性消化不良的随机对照试验(randomized controlled trial，RCT)，进行Meta分析。运用中医传承辅助平台对含柴胡方剂进行分析。结果 最终纳入50篇文献，共计4593例患者。方剂分析结果显示，含柴胡制剂临床治疗抑郁症和功能性消化不良时，柴胡常用剂量为6～15 g，且常与龙骨、牡蛎、枳壳、白芍、炙甘草、茯苓等药配伍；Meta分析结果显示，在治疗这3类疾病时，含柴胡制剂治疗总有效率显著高于常规治疗方案 [RR＝1.21，95%CI(1.18，1.24)，P＜0.000 01]；不良反应发生率显著低于常规治疗方案 [RR＝0.37，95%CI(0.32，0.44)，P＜0.000 01]。结论 含柴胡制剂治疗抑郁症、上呼吸道感染、功能性消化不良均具有显著的疗效及安全性，但受纳入文献的质量及数量影响，仍需开展大样本、多中心RCT研究加以验证。

Objective To evaluate the effectiveness and safety of the preparations containing Chaihu (Bupleuri Radix) in the treatment of depression, upper respiratory infection and functional dyspepsia. Methods Randomized controlled trials (RCTs) of preparations or descriptions containing Bupleuri Radix in the treatment of aboved diseases were collected from CNIK, Wanfang Date, PubMed, Web of Science and Cochrane Library from their establishment to July, 2022, and Meta-analyses were performed. The prescription containing Bupleuri Radix was analyzed using the traditional Chinese medicine inheritance auxiliary platform. Results A total of 50 RCTs studies were eventually included in the study for a total of 4593 cases. The results of prescription analysis showed that when Bupleuri Radix was used in the clinical treatment of depression and functional dyspepsia, the dosage of Bupleuri Radix was 6—15 g, and it was often compatible with Longgu (Os Draconis), Muli (Ostreae Concha), Zhiqiao (Aurantii Fructus), Baishao (Paeoniae Radix Alba), Zhigancao (Glycyrrhizae Radix et Rhizoma Praeparata cum Melle) and Fuling (Poria). The results of Meta-analysis showed that in the treatment of these three diseases, the total effective rate of preparation containing Bupleuri Radix was significantly higher than that of conventional treatment [RR = 1.21, 95%CI (1.18, 1.24), P＜0.000 01]. The incidence of adverse reactions was significantly lower than that of conventional treatment [RR = 0.37, 95%CI (0.32, 0.44), P＜0.000 01]. Conclusion The preparation containing Bupleuri Radix has significant efficacy and safety in the treatment of depression, upper respiratory infection and functional dyspepsia. However, due to the quality and quantity of the included literature, large-sample and multi-center RCT studies are still needed to be verified.

R285.64

国家自然科学基金项目(81873194)；国家中医药管理局青年歧黄学者支持项目