中药配伍是中医药临床应用的精华之一，合理配伍是保障中药临床用药有效性和安全性的重要措施。配伍后减毒增效机制的研究是诠释中药配伍合理性的关键内容。中药配伍机制研究正处于从体外到体内、成分到靶标、单一技术到多学科融合研究技术的转变历程，因此提出以“体外成分、体内过程、直接靶标”研究为基础，“中药配伍药理机制研究”为目的，从不同角度和不同层面探索中药配伍后作用机制的研究策略。

Traditional Chinese medicine (TCM) compatibility is one of the essences of TCM clinical practice, and rational compatibility is an important measure to ensure the effectiveness and safety of clinical use of TCM. The study of mechanisms of toxicity reduction and potency enhancement after compatibility is a key element in interpreting the rationality of TCM compatibility. Research on mechanisms of TCM compatibility is in the process of transitioning from in vitro to in vivo, from composition to target, and from a single technique to multidisciplinary integration of research techniques. Therefore, a research strategy based on study of “in vitro components, in vivo processes and direct targets” and “the study of pharmacological mechanisms of TCM compatibility” as the objective was proposed in this paper, which explores research strategies on mechanism of action of TCM after compatibility from different perspectives and at different levels.

R285.62

国家自然科学基金资助项目(81873194)；国家自然科学基金资助项目(81903938)；国家中医药管理局青年岐黄学者支持项目