肾脏相关疾病是目前临床上较为常见的一系列疾病的总称，主要包括肾结石、痛风性肾病、糖尿病肾病、肾衰竭、肾病综合征等。临床上主要表现为蛋白尿、血尿、水肿、高血压等症状。目前对于此类疾病的治疗大多采用西医疗法，不良反应较多，且疗效欠佳。肾茶Clerodendranthus spicatus作为我国壮族、傣族等少数民族常用草药，具有利尿排石、抗炎、调节肾功能等作用，大量民间应用经验表明其对肾脏相关疾病具有神奇疗效，无不良反应。对肾茶提取物及活性成分现代药理作用和临床研究进展进行系统梳理和归纳分析，以期为肾茶治疗肾脏疾病的深入机制研究和临床应用提供参考。

Kidney-related-disease is a general name of a series of common clinical diseases, including kidney stones, gouty nephropathy, diabetes nephropathy, renal failure, nephrotic syndrome, etc. The main clinical manifestations are proteinuria, hematuria, edema, hypertension and other symptoms. At present, western medicine is mostly used in the treatments of these kinds of diseases, with many side effects and poor curability. Cleodendranthus spicatus, as a commonly used herbal medicine of Zhuang, Dai and other ethnic minorities in China, possesses the effects of diuresis, stone excretion, anti-inflammatory and regulating renal functions. A large number of folk application experiences showed that it owned magical curative effects on kidney related diseases without toxic and side effects. This paper systematically combed and summarized the modern pharmacological effects and clinical research progresses of C. spicatus extracts and its active components, in order to provide a reference for deeper researches on its pharmacological mechanisms and clinical applications in the treatments of kidney diseases.

R286

广东省自然科学基金资助项目(2021A1515011485)