目的 对三白草Saururus chinensis地上部分的化学成分及其抗氧化活性进行研究。方法 采用MCI HP20、硅胶、Sephadex LH-20等多种色谱材料进行分离纯化，根据波谱数据鉴定化合物的结构。采用DPPH方法和ABTS方法评价各化合物的体外抗氧化活性。结果 从三白草地上部分丙酮提取物中分离得到17个化合物，分别鉴定为里卡灵A（1）、里卡灵B（2）、二氢愈疮木脂酸（3）、rel-(8S,8'R)-dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl) tetrahydrofuran（4）、odoratisol C（5）、nectandrin B（6）、三白草酮（7）、surinomensin（8）、樟叶素（9）、三白草醇E（10）、三白草醇（11）、马萨婷B（12）、stigmasta-4,22-dien-3-one（13）、(24R)-24-ethylcholest-4-en-3,6-dione（14）、sauruchinenol A（15）、邻苯二甲酸二丁酯（16）、丹皮酚（17）。结论 化合物17为首次从该属植物中分离得到，化合物4、5、13、14为首次从该植物中分离得到，化合物1、3、7、11具有一定的体外抗氧化活性。

Objective To study the chemical constituents and antioxidant activity of the aerial parts of Sanbaicao (Saururus chinensis). Methods The chemical constituents were isolated and purified by column chromatography on MCI HP20, silica gel, and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic data. DDPH and ABTS method were used to determine the antioxidant activity of the isolated compounds. Results Seventeen compounds were isolated from acetone extract of Saururus chinensis. The structures were identified as licarin A (1), licarin B (2), dihydroguaiaretic acid (3), rel-(8S,8'R)-dimethyl-(7S,7'R)-bis (3,4-methylenedioxyphenyl) tetrahydrofuran (4), odoratisol C (5), sauchinone (6), sauchinone (7), surinomensin (8), polysyphorin (9), and sauceneol E (10), saucerneol (11), manassantin B (12), tigmasta-4,22-dien-3-one (13), (24R)-24-ethylcholest-4-en-3,6-dione (14), sauruchinenol A (15), dibutyl phthalate (16), paconol (17). Conclusion Compound 17 is isolated from Saururus genus for the first time, compounds 4, 5, 13, and 14, are isolated from this plant for the first time. In addition, Compounds 1, 3, 7, and 11 were found to have potential antioxidant activities.

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云南省科技厅-云南省地方本科高校基础研究联合专项项目(2017FH001-094and2017FH001-092);云南省教育厅科学研究基金资助性项目(2016ZZX208);地方高校国家级大学生创新创业训练计划项目(201610684010);云南省科技厅应用基础研究青年项目(2018FD081)