经典名方一贯煎出自清代魏之琇所著《续名医类案》，为滋阴疏肝之良方。从历史沿革、化学成分和药理作用等方面对一贯煎的研究进展进行综述。根据中药质量标志物（quality marker，Q-Marker）的“五原则”对一贯煎Q-Marker进行预测分析，结果显示花椒毒素、佛手柑内酯、补骨脂素、法卡林二醇、甲基麦冬高异黄酮A、甲基麦冬高异黄酮B、甲基麦冬黄烷酮A、甲基麦冬黄烷酮B、鲁斯可皂苷元、洋川芎内酯I、藁本内酯、阿魏酸、梓醇、地黄苷D、毛蕊花糖苷、甜菜碱和川楝素可作为一贯煎的Q-Marker，为其后续基准样品的制备和新药研发提供参考。

Yiguan Decoction (一贯煎), a classical prescription of nourishing yin and soothing liver and treating yin deficiency of liver and kidney, is contained in the Xumingyi Leian written by Wei Zhixiu in the Qing Dynasty. Research progress on historical evolution and chemical constituent and pharmacological effect of Yiguan Decoction were reviewed in this paper. According to “five principles”, the quality markers (Q-Markers) of Yiguan Decoction were predicted in this paper. The results suggested that xanthotoxin, bergapten, psoralen, falcarindiol, methylophiopogonone A, methylophiopogonone B, methylophiopogonanone A, methylophiopogonanone B, ruscogenin, senkyunolide I, ligustilide, ferulic acid, catalpanol, rehmannioside D, calorioside, betaine and azadirachtin could be used as Q-Markers for Yiguan Decoction, which could provide basis and reference for the subsequent preparation of reference samples and further study of preparations.

R282.710.5

国家重点研发计划项目(2020YFE0205600);中国科学院青年创新促进会优秀会员项目(Y202086);王宽诚教育基金会资助项目