多糖是高等植物、动物细胞膜和微生物细胞壁的重要组成部分，在自然界中广泛存在，是一种重要的天然生物大分子，具有多种生物活性。非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）是一种以肝细胞内脂质过载为特征的慢性肝病。近年来，研究发现中药多糖可通过调节脂质代谢紊乱、调节肠道菌群、减轻胰岛素抵抗与氧化应激、改善线粒体功能障碍等多种途径改善NAFLD。归纳总结了近年来中药多糖改善NAFLD的药理作用及相关机制，以期为多糖在NAFLD防治中的治疗应用提供一定的理论参考。

Traditional Chinese medicine polysaccharides are important components of cell membranes of higher plants, animal and cell walls of microorganisms, and are widely found in nature as an important natural biomolecule with a variety of biological activities. Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by lipid overload in hepatocytes. In recent years, traditional Chinese medicine polysaccharides have been found to improve NAFLD by regulating lipid metabolism disorders, regulating intestinal flora, reducing insulin resistance and oxidative stress, and improving mitochondrial dysfunction. In this paper, related research on role and mechanism of traditional Chinese medicine polysaccharides in improving NAFLD in recent years was reviewed, in order to provide a theoretical basis for the therapeutic application of polysaccharides in prevention and treatment of NAFLD.

R282.710.5

安徽省自然科学基金资助项目(1908085MH248);安徽省高校自然科学研究重大项目(KJ2021ZD0101);皖南医学院科学研究“揭榜挂帅”专项项目(WK2022J02);芜湖市科技项目(2022cg20)