目的 运用频率学网状Meta分析评价口服中成药联合常规化学药治疗多囊卵巢综合征（polycystic ovary syndrome，PCOS）的有效性和安全性。方法 检索中国知网（CNKI）、万方（Wanfang）、维普（VIP）、中国生物医学文献数据库（SinoMed）、读秀（Duxiu）、PubMed、Embase、Cochrane Library、Web of Science、Ovid、Scopus数据库中口服中成药治疗PCOS的随机对照试验（randomized controlled trials，RCTs），检索时间为建库至2022年5月。2名研究者按照纳排标准独立提取文献信息，采用Cochrane偏倚风险评估工具对纳入文献进行质量评价，用RevMan5.4、Stata/SE17.0软件进行数据分析。结果 最终纳入32项RCTs，涉及9种中成药，样本量为3534例。网状Meta分析结果显示，在降低血清睾酮水平方面，排名前3的干预措施分别为坤泰胶囊＋常规化学药、丹参酮胶囊＋常规化学药、培坤丸＋常规化学药；在降低促黄体生成素水平方面，排名前3的干预措施分别为丹参酮胶囊＋常规化学药、培坤丸＋常规化学药、麒麟丸＋常规化学药；在改善胰岛素抵抗指数方面，排名前3的干预措施分别为百令胶囊＋常规化学药、红花逍遥片＋常规化学药、坤泰胶囊＋常规化学药；在改善血三酰甘油水平方面，排名前3的干预措施分别为丹参酮胶囊＋常规化学药、百令胶囊＋常规化学药、定坤丹＋常规化学药；安全性方面，不良反应较少的前3种干预措施分别为妇科再造胶囊＋常规化学药、定坤丹＋常规化学药、复方玄驹胶囊＋常规化学药。结论 口服中成药联合常规化学药可有效提高治疗PCOS的临床疗效，安全性良好，但受到研究质量及样本量限制，仍需要大样本、高质量的试验对结果进一步验证。

Objective To evaluate the efficacy and safety of oral Chinese patent medicines combined with conventional western medicine in the treatment of polycystic ovary syndrome (PCOS) by frequency network Meta-analysis.Methods The randomized controlled trials (RCTs) on oral Chinese patent medicines in the treatment of PCOS were retrieved from CNKI, Wanfang, VIP, SinoMed, Duxiu, PubMed, Embase, Cochrane Library, Web of Science, Ovid and Scopus databases from the time of database establishment to May 2022. Two researchers independently extracted literature data according to inclusion and exclusion criteria, the quality of the included RCTs was evaluated according to the Cochrane bias risk assessment tool, and the data was analyzed by RevMan 5.4 and Stata/SE 17.0.Results A total of 32 RCTs were included, involving nine kinds of oral Chinese patent medicines and 3534 patients. The results of the network Meta-analysis showed that the top three optimal medication regimens in reducing serum testosterone levels were conventional western medicine respectively combined with Kuntai Capsules (坤泰胶囊), Danshentong Capsules (丹参酮胶囊), and Peikun Pills (培坤丸). The top three optimal medication regimens in reducing luteinizing hormone levels were conventional western medicine respectively combined with Danshentong Capsules, Peikun Pills, and Qilin Pills (麒麟丸). The top three optimal medication regimens in improving insulin resistance were conventional western medicine respectively combined with Bailing Capsules (百令胶囊), Honghua Xiaoyao Tablets (红花逍遥片), and Kuntai Capsules. The top three optimal medication regimens in reducing blood triglycerides levels were conventional western medicine respectively combined with Danshentong Capsules, Bailing Capsules, and Dingkun Dan (定坤丹). In terms of safety, the top three optimal medication regimens were conventional western medicine respectively combined with Fukezaizao Capsules (妇科再造胶囊), Dingkun Dan, and Fufang Xuanju Capsules (复方玄驹胶囊).Conclusions The oral Chinese patent medicines combined with conventional therapy can effectively improve the clinical efficacy of the treatment of PCOS, with good safety. However, limited by the quality and quantity of literature included in this study, large samples and high-quality trials are still needed to further verify the results.

R285.64

国家自然科学基金项目(81674011);中国中医科学院科技创新工程(CI2021A02404)