目的 探讨紫龙金片对老年非小细胞肺癌的疗效及预后影响因素。方法 利用真实世界前瞻性队列研究的方法,以是否服用紫龙金片划分为紫龙金片组及非紫龙金片组,提取患者人口学、诊断、治疗、中医辨证、症状等信息,比较两组临床疗效及一年生存率,并进行生存分析。结果 最终205例患者被纳入统计分析,其中紫龙金片组99例,非紫龙金片组106例;紫龙金片组一年生存率显著高于非紫龙金片组(67.7%vs44.3%,P<0.05)。生存分析显示,紫龙金片组的平均生存时间为10.37个月,非紫龙金片组为8.88个月,两组差异具有统计学意义(P=0.001,P<0.01)。Cox回归分析显示,是否服用紫龙金片是死亡终点事件的独立影响因素,服用紫龙金是独立保护因素,并降低了60%的死亡风险[P<0.001,HR=0.400,95%CI(0.239,0.669)]。结论 紫龙金片可以提高老年非小细胞肺癌患者的生存率,并能延长生存时间。

Objective To investigate the efficacy and prognostic influencing factors of Zilongjin Tablets (紫龙金片) in treatment of elderly non-small cell lung cancer. Methods Using the method of prospective clinical study in the real-world, patients were divided into the Zilongjin Tablets group and the non-Zilongjin Tablets group according to whether they took Zilongjin Tablets or not, the information of patient demographics, diagnosis, treatment, Chinese medicine syndrome differentiation and symptoms were extracted. The clinical efficacy and one-year survival rate of the two groups were compared, and survival analysis was conducted. Results The final statistical analysis included 205 patients, including 99 cases in the Zilongjin Tablets group and 106 cases in the non-Zilongjin Tablets group; and the one-year survival rate in the Zilongjin Tablets group was significantly higher than that in the non-Zilongjin Tablets group (67.7% vs 44.3%, P< 0.05). Survival analysis showed that the mean survival time was 10.37 months in the Zilongjin Tablets group and 8.88 months in the non-Zilongjin Tablets group, with a significant difference between the two groups (P= 0.001, P< 0.01). Cox regression analysis showed that whether or not to take Zilongjin Tablets was an independent prognostic factor for the endpoint event of death, and taking Zilongjin Tablets was an independent protective factor, which reduced the risk of death by 60% [P< 0.001， HR = 0.400， 95%CI (0.239, 0.669)]. Conclusion Zilongjin Tablets can improve the survival rate and prolong the survival time of elderly patients with non-small cell lung cancer.

R285.64

省部共建中医湿证国家重点实验室项目（SZ2021ZZ38）；广东省基础与应用基础研究企业联合基金项目（2021A1515220023）