霍山石斛Dendrobium huoshanense是我国的珍贵中药材，大量药理实验阐明霍山石斛在治疗肝脏疾病方面有显著疗效，从调节抗氧化水平、抑制炎症、抑制转化生长因子-β1和I、III胶原蛋白合成、减少肝脏脂质沉积等方面对肝脏疾病产生治疗作用。对霍山石斛化学成分和霍山石斛活性成分治疗肝脏疾病，如酒精性肝损伤、非酒精性肝损伤、化学性肝损伤、药物性肝损伤、肝纤维化的药理作用及其机制进行综述，为霍山石斛的资源利用和肝脏疾病的新药开发提供一定的理论基础。

Dendrobium huoshanense is a precious traditional Chinese medicinal material in China. A large number of pharmacological experiments have demonstrated that D. huoshanense had significant curative effects in the treatment of liver diseases, from regulating antioxidation levels, inhibiting inflammation, inhibiting transforming growth factor-β1 and I, III collagen, reducing hepatic lipid deposition, and other aspects in the treatment of liver diseases. The article reviews the pharmacological effects and mechanisms of the chemical constituents and active ingredients of D. huoshanense in treating liver diseases, including alcoholic liver disease, non-alcoholic fatty liver disease, chemical liver injury, drug-induced liver injury and liver fibrosis, which could serve to guide drug discovery for liver diseases and resource utilization of D. huoshanense.

R284.1

国家自然科学基金联合基金项目（U19A2009）；安徽高校协同创新项目（GXXT-2019-043）；省部共建安徽道地中药材品质提升协同创新中心项目（教科信厅函[2022]4号）；安徽省教育厅项目（皖教秘科[2014]44号）