防己Stephania tetrandra是一味使用历史悠久的中药,最早出现于《神农本草经》中。其味苦,性寒,归膀胱﹑肺经,具有祛风止痛、利水消肿之功效,用于治疗风湿痹痛、水肿脚气、小便不利、湿疹疮毒等病症。对防己的化学成分和现代药理研究进行综述,从防己特有化学成分、药理活性的药效物质基础和网络药理学3个方面对防己的质量标志物(quality markers,Q-Marker)进行预测分析,为防己质量控制提供科学依据。

Stephania tetrandra is a traditional Chinese medicine with a long history of use,first appearing inShennong Materia Medica Classic.It is bitter in taste,cold in nature,and belongs to the bladder and lung meridian.It has the effect of dispelling wind and relieving pain,diuresis and detumescence,used for the treatment of rheumatism arthralgia,edema beriberi,adverse urination,eczema and other diseases.In this paper,the chemical components and pharmacological effects ofS.tetrandra were summarized and reviewed.The quality markers ofS.tetrandra were predicted and analyzed from three aspects:Unique chemical composition,material basis for pharmacological effects based on pharmacological research,and network pharmacology,which provides scientific basis for the research on the quality control ofS.tetrandra.

2019年博士科研启动基金项目(2019BS028);广西中医药大学2021年研究生区级创新科研项目(YCSW2021238);广西中药药效研究重点实验室课题(19-050-39);农作物废弃物功能成分研究协同创新中心建设项目(CICAR2017-Z1)