抑郁症是一种难以调控的疾病,目前缺乏高效、稳定且安全的抗抑郁药,寻找抑郁症发病新机制对抗抑郁药物的研发具有重要意义。近年来,研究发现抑郁症与内源性大麻素系统(endocannabinoid system,ECS)的紊乱密切相关,然而涉及的机制较为复杂,亟待整理。当下,通过ECS的调控来治疗抑郁症是一种新途径,而中药在该途径上存在天然优势,从中开发抗抑郁新药具有广泛的研究前景。鉴于此,对ECS与抑郁症的关系及中药介导ECS发挥抗抑郁作用的潜力进行了分析,以期为抑郁症发病机制的研究提供参考,为抗抑郁药物的研发提供新策略。

Depression was a disease that was difficult to control,and satisfactory medication was lacking.From this perspective,the discovery of new pathogenesis for depression had important significance for the development of antidepressant drugs.In recent years,studies have found that depression was closely related to the disturbance of endocannabinoid system (ECS),but the mechanism involved was complex.At present,it was a new way to treat depression through the regulation of ECS,and traditional Chinese medicine had some natural advantages in this way.In this regard,the development of new antidepressant drugs had broad research prospects.In view of this,present study analyzed the relationship between ECS and depression,and also analyzed the antidepressant effects of ECS mediated by traditional Chinese medicine.The main purpose of this study was to provide a reference for the research of the pathogenesis of depression,and provide new strategies for the development of antidepressant drugs.

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国家自然科学基金面上项目(82074323);国家自然科学基金面上项目(81673572);国家重大新药创制科技重大专项(2017ZX09301047);山西省留学回国人员科技活动择优资助项目(201991);山西省回国留学人员科研资助项目(2020019)