板蓝根多糖是板蓝根的主要成分,具有多种药理作用,其中抗病毒作用较为突出,可通过多种方式实现,如直接杀灭病毒和抑制病毒吸附、复制及蛋白表达,还可通过促进免疫细胞增殖分化、促进细胞因子释放、降低促炎因子水平以及参与红细胞免疫等方式增强机体的免疫作用,Toll样受体3(toll-likereceptor-3,TLR3)通路和Janus激酶(Janus kinase,JAK)/信号转导子和转录激活因子(signal transducer and activator of transcription,STAT)通路是其通过免疫调节方式抗病毒的重要信号通路,免疫佐剂的应用可为板蓝根多糖与其他抗病毒制剂的联合使用提供一定思路。主要综述了板蓝根多糖抗病毒作用及其机制的研究进展,以期为板蓝根多糖的临床应用提供参考。

Isatidis Radix polysaccharide is the main component of Banlangen (Isatidis Radix),which has a variety of pharmacological effects.Among them,the anti-virus effect is more prominent,which can be achieved in a variety of ways,such as direct killing,inhibiting virus adsorption,replication and protein expression.It can also enhance the immune function of the body by promoting the proliferation and differentiation of immune cells,promoting the release of cytokines,reducing the level of proinflammatory factors and participating in erythrocyte immunity,TLR3 and JAK/STAT are important signal pathways for anti-virus through immune regulation.The application of immune adjuvant can provide some ideas for the combination ofIsatidis Radix polysaccharide and other antiviral agents.Research progress on antiviral effect and mechanism ofIsatidis Radix polysaccharide were reviewed in this paper,in order to provide reference for clinical use ofIsatidis Radix polysaccharide.

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国家自然科学基金资助项目(81960713);国家自然科学基金资助项目(82160750);国家药品监督管理局中药材及饮片质量控制重点实验室项目(2020GSMPA-KL15);甘肃省教育厅产业支撑计划项目(2021CYZC-21);甘肃省中药制药工艺工程研究中心开放课题(ZYGY202003);甘肃省科技计划(创新基地与人才计划)基础研究创新群体项目(21JR7RA569)