目的 系统全面分析比较通体结香技术产沉香（简称通体香）与野生沉香化学成分，为通体结香技术进一步的应用和推广提供科学可靠的依据。方法 采用超高效液相色谱串联四级杆飞行时间质谱（UPLC-Q/TOF-MS）和气相色谱-质谱（GC-MS）结合非靶向代谢组学和指纹图谱，对通体香与野生沉香的乙醇提取物和挥发性成分进行分析。结果 16批通体香与16批野生沉香的共有成分相同，但通体香指纹图谱相似度较高，且4个倍半萜、3个小分子芳香物质和8个2-(2-苯乙基)色酮等共17个共有成分在通体香中含量较高。结论 通体香和野生沉香主要化学成分组成相同，但不同批次间通体香的质量更稳定。

Objective To provide scientific basis for the advanced application and popularization of agarwood produced by Whole-tree agarwood-inducing technique (Agar-Wit), the compositional differences between agarwood induced by Agar-Wit and natural agarwood were analyzed and compared in the study. Methods The ethanol extracts and volatile components of samples were analyzed by ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and gas chromatography-mass spectrometry (GC-MS) combined with non-targeted metabolomics and fingerprint in this study. Results The common components of agarwood induced by Agar-Wit were consistent with natural agarwood. The similarity coefficients among Agar-Wit agarwood were higher than that in natural agarwood. In addition, the content of three low-molecular-weight aromatic compounds, four kinds of sesquiterpenes and eight 2-(2-phenylethyl)chromones were richer in agarwood induced by Agar-Wit. Conclusion The main chemical composition of agarwood induced by Agar-Wit, which is more stable, is proved to be in accordance with wild agarwood.

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国家重点研发计划项目（2018YFC1706403）；海南省自然科学基金高层次人才项目（2019RC340）；现代农业产业技术体系建设专项（CARS-21）；中国医学科学院医学与健康科技创新工程项目（2016-I2M-2-003）；2021年国家药品标准提高课题（2021Z14）