随着“一带一路”倡议的持续推进，中外文化交流日益频繁，大量外来药用资源品种涌入国内，丰富了中药资源的同时也面临着和中药配伍应用及如何规范使用等诸多问题。因此赋予外来药物中药药性及其功效，将外来药用资源“中药化”是目前亟待解决的关键科学问题之一。对外来药用资源“中药化”的方法体系进行综述，总结历代外来药用资源中药化的认识方法，结合现代科学技术，分析外来药用资源的研究规律及策略，即“理论推导（象思维＋文献研究）→原产地考证→实验研究（网络药理学＋代谢组学）→明确物质基础组分结构特征→临床实践”反复探索思路，同时充分考虑外来资源毒性和生物安全问题，以促进外来药用资源研究的系统化、标准化、科学化。为新外来资源中药化提供研究思路，推动实现中药的现代化与国际化发展。

With the continuous promotion of the "Belt and Road" initiative, sino-foreign cultural exchanges have become increasingly frequent, and a large number of foreign medicinal resources have flooded into China, enriching the resources of traditional Chinese medicine (TCM), but also facing many problems such as compatibility with TCM and how to standardize its use. Therefore, it is one of the key scientific problems that need to be solved urgently to endue foreign medicines with properties and effects of TCM and to introduce the foreign medicine to TCM. In this paper, the existing methods system of "introducing the foreign medicinal resources to TCM" were reviewed, the understanding methods of introducing foreign medicinal resources to TCM in past dynasties were summarized, and the research rules and strategies of foreign medicinal resources were analyzed in combination with modern techniques, that is, "theoretical derivation (Xiang thinking + literature research) → local textual research → experimental research (network pharmacology + metabolomics) → definite structural characteristics of material base components → clinical practice". Meanwhile, toxicity and biosafety problems of foreign resources are fully considered, so as to promote the systematization, standardization and scientization of foreign medicinal resources research. It provides a research idea for introducing new foreign medicinal resources to TCM and promotes the modernization and international development of TCM.

国家重点研发计划中药现代化专项（2018YFC1706900）；中国药科大学双一流创新团队（CPU2018GY11）；天然药物活性组分与药效国家重点实验室资助项目（SKLNMZZ202025）；江苏省科技成果转化专项资金（BA2020077）