胡黄连Picrorhizae Rhizoma为中医临床清虚热要药，目前一般认为其功效与环烯醚萜类、苯乙醇糖苷类和酚苷类化合物相关，而对于胡黄连所含葫芦烷型四环三萜类化合物及其生物活性关注较少。研究表明含有α,β-不饱和酮结构的葫芦烷型四环三萜属于迈克尔反应受体小分子，具有抗肿瘤等重要药理活性。对胡黄连中的葫芦烷型四环三萜类化合物进行综述，一方面比较了2种基原胡黄连所含葫芦烷型四环三萜类化合物的差异，另一方面对此类化合物的生物活性研究进行总结，为深入探索胡黄连功效的物质基础提供参考。

Huhuanglian (Picrorhizae Rhizoma) is used for clearing asthenic fever in traditional Chinese medicine. It has been believed that these effects are related with iridoids, phenylethanol glycosides and phenolic glycosides in Picrorhizae Rhizoma. However, there is little attention on cucurbitane-type tetracyclic triterpenoids and their bioactivities. Studies have shown that cucurbitacins containing α, β-unsaturated ketones belong to Michael reaction receptor molecules, which exert important pharmacological activities such as anti-tumor. Cucurbitane-type tetracyclic triterpenes in Picrorhizae Rhizoma are reviewed in this paper. The distinction in cucurbitacins between Picrorhizae Rhizoma of Picrorhiza kurroa and Picrorhiza scrophulariiflora and bioactivities of cucurbitacins are systematacially summarized, in order to provide reference for further exploring material basis of efficacy of Picrorhizae Rhizoma.

R282.710.5

科技部国家重点研发计划项目(2019YFC1709600);国家自然科学基金面上项目(81873297);国家自然科学基金面上项目(81973672)