代谢组学作为系统生物学的重要组成部分，与中医药基础理论的“整体观”具有一致性，通过现代分析技术手段检测生物体系内代谢产物的变化，更准确、直接地反映生物体系的终端和表型信息，揭示中医药治疗复杂疾病的作用机制。将中医药研究与代谢组学方法相互结合是中医药现代化进程的重要之举，为探求中医药研究新思路和新方法奠定重要基础。通过对近10年相关研究成果进行归纳，概述代谢组学在中医证候、中药作用机制、中药安全性评价和中药质量控制等方面的应用和研究进展，分析和总结代谢组学在中医药领域中的研究方法，并提出代谢组学在中医药研究中的思考和展望。

As an important part of systems biology, metabolomics is consistent with the "holistic view" of the basic theories of traditional Chinese medicine (TCM). Metabolomics detects changes in metabolites in biological systems through modern analytical techniques, more accurately and directly reflects the terminal and phenotypic information of biological systems, and reveals the mechanism of TCM in the treatment of the complex diseases. It is an important step in the modernization of TCM to combine TCM research with metabolomics, which lays an important foundation for exploring new ideas and methods in the research of TCM. This study aims to summarize the relevant research results in the past ten years, summarize the application and research progress of metabolomics in Chinese medicine syndromes, mechanism, safety evaluation and quality control of TCM, analyze and summarize research methods of metabolomics in the field of TCM, and put forward the thinking and prospect of metabolomics in TCM research.

国家重点研发计划项目(2019YFC1708900);中央级公益性科研院所基本科研业务费专项资金资助(JBGS2021002);中国中医科学院科技创新工程项目资助(CI2021A05031)