目的 基于中医药方剂数据库，对含酸枣仁-远志药对的方剂数据进行挖掘，研究酸枣仁-远志药对的配伍特点及应用规律，为其临床实践及科学研究提供指导。方法 检索含酸枣仁-远志药对的方剂数据，对方剂功效，酸枣仁、远志炮制品种、剂量、配比等进行统计分析。运用SPSS Modeler、Cytoscape将酸枣仁、远志炮制品种、剂量及配比与功效分别进行网络关联分析。结果 共检索得到484首含酸枣仁-远志药对的方剂，涉及336味中药。目标方剂主要涉及安神、补益等18种功效。酸枣仁包含生、炒、去油3种炮制品，炒酸枣仁使用频次最多，且与安神、补益、化痰、益智等功效呈强关联；远志包含远志肉、制远志等15种炮制品，其中远志肉、制远志使用频次较高，且与安神、补益呈现强关联。酸枣仁剂量主要分布于3～5 g、6～10 g、15～35 g剂量段，且与安神、补益等呈现强关联；远志在＜3 g、3～5 g、6～10 g、12～35 g剂量段呈正态性分布趋势，且主要分布于3～5 g，与安神呈现强关联。酸枣仁-远志配比以≥1为主，且以配比1∶1、2∶1多见，与安神、补益呈现强关联，此外，配比1∶1与益智、化痰亦呈现强关联。与酸枣仁-远志药对配伍使用较多的药物主要包括人参、当归、茯神、地黄等42味，与其配伍形成高频角药。结论 通过对酸枣仁-远志药对及其与功效间的关系进行挖掘分析，揭示了酸枣仁-远志用药模式及其配伍特点，阐明了其临床应用规律，为该药对临床应用及深入研究提供科学指导。

Objective To study the compatible characteristics of Suanzaoren (Ziziphi Spinosae Semen, ZSS)-Yuanzhi (Polygalae Radix, PR) herb pair by data mining based on the database of traditional Chinese medicine (TCM) prescriptions and provide guidance for modern clinical practice and scientific research of TCM. Methods The prescriptions containing the ZSS-PR herb pair were retrieved to analyze the efficacy, processed products, dosage and proportion of ZSS and PR. SPSS Modeler and Cytoscape were used to carry out network correlation analysis on the processed products, dosages, proportion and efficacy of ZSS and PR. Results A total of 484 TCM prescriptions containing ZSS and PR were obtained, involving 336 TCMs. The target prescriptions mainly involved 18 effects such as sedative and tonifying effects. ZSS included three processed products:crude, baked and deoiled. The baked ZSS was used most frequently and strongly correlated with the sedative and tonifying, phlegm dissipating, and benefiting intelligence effects. Similarly, PR included 15 kinds of products, among which PR without wooden heart and proceeded PR were used most frequently and strongly correlated with the sedative and tonifying effects. The dose of ZSS was distributed in 3-5 g, 6-10 g, and 15-35 g and strongly correlated with the sedative and tonifying effects. The dose of PR was distributed in < 3 g, 3-5 g, 6-10 g, and 12-35 g, among which 3-5 g was the primary dose frequency and strongly correlated with the sedative and tonifying effects. The proportion of ZSS and PR was mainly ≥ 1, and 1:1 or 2:1 was more common, which was strongly related to sedative and tonifying effects. In addition, the proportion of 1:1 was also strongly related to benefiting intelligence and resolving phlegm effects. There are 42 high-frequency compatible TCMs with ZSS-PR herb pairs, such as Renshen (Ginseng Radix et Rhizoma), Danggui (Angelicae Sinensis Radix), Fushen (Poria cum Radix Pini), Dihuang (Rehmanniae Radix), etc., which form a high-frequency horn drug. Conclusion By analyzing the relationship between the ZSS-PR herb pair and their efficacy, the pattern of medication and compatibility characteristics of ZSS and PR were revealed, and the rules of clinical application were clarified, with view to providing guidance for the clinical practice and scientific research of ZSS-PR herb pair.

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山西省基础研究计划项目(20210302124294);山西省高等学校科技创新项目(2021L361);山西省回国留学人员科研资助项目(2021-143)