目的 研究丁香蒲桃Syzygium aromaticum的果实母丁香的化学成分。方法采用硅胶柱色谱、SephadexLH-20凝胶柱色谱及半制备高效液相色谱法分离纯化，采用MS、¹H-NMR、¹³C-NMR、DEPT、HSQC、HMBC、COESY等波谱学方法鉴定化合物的结构。结果 从母丁香乙醇提取物中分离得到了15个化合物，分别鉴定为1,3,5-三羟基-3-甲基苯乙酮-1-O-β-D-(6'-O-没食子酰基)葡萄糖苷（1）、triterpenoster（2）、积雪草酸（3）、齐墩果酸（4）、山楂酸（5）、熊果酸（6）、花椒油素（7）、methylxanthoxylin（8）、母丁香酚（9）、没食子酸（10）、没食子酸甲酯（11）、丁香酚（12）、萎叶醇（13）、β-氧化石竹烯（14）、去氢双丁香酚B（15）。结论 化合物1为新化合物，命名为母丁香酚A；化合物2为新天然产物，化合物7～8、11首次从该植物中分离得到。化合物1、7～9为苯乙酮类成分，2～3为乌苏烷型三萜类成分，4～5为齐墩果烷型三萜类成分，12～13、15为苯丙素类成分，14为倍半萜类成分。

Objective To study on the chemical constituents from the fruits of Syzygium aromaticum. Methods The chemical constituents were separated and purified by Sephadex LH-20, silica gel, semi-prepared HPLC and other chromatography techniques. Their structures were elucidated by MS and NMR data. Results Fifteen compound were isolated, and were identified as 1,3,5-trihydroxy-3-methylacetophenone-1-O-β-D-(6'-O-galloxyl)glucoside (1), triterpenoster (2), asiatic acid (3), oleanolic acid (4), maslinic acid (5), ursolic acid (6), xanthoxylin (7), methylxanthoxylin (8), bancroftione (9), gallic acid (10), methyl gallate (11), eugenol (12), chavibetol (13), β-caryophyllene oxide (14), dehydrodieugend B (15). Conclusion Compound 1 is a new compound named syzygiumol A. Compounds 2 is isolated as a new natural compound. Compounds 7-8 and 11 are isolated from this plant for the first time. Compounds 1, 7-9 are acetophenone; Compounds 2-3 are ursane-type triterpenoids; Compounds 4-5 are oleanane-type triterpenoids; Compounds 12-13, 15 are phenylpropanoids; Compounds 14 is sesquiterpenoid.

R284.1

天津市教委科研计划项目(2019ZD031)