目的 基于真实世界探索喜炎平注射液治疗病毒性脑炎的用药规律,为临床合理用药提供参考。方法 从中国中医科学院中医临床基础医学研究所构建的真实世界电子医疗数据库中提取喜炎平注射液治疗病毒性脑炎患者的医疗电子病历10 845例,采用Tabu搜索算法及复杂网络分析,对结果进行归纳得到临床用药规律。结果 纳入使用频次大于11的合并中西药共119种,获得最优划分的35种药物子群及复杂网络图,展现了喜炎平注射液联合其他药物治疗病毒性脑炎的最佳临床合并用药特征。结论 喜炎平注射液治疗病毒性脑炎的药物治疗包括抗病毒、对症支持、合并症及后遗症治疗的方案,上述方案与病毒性脑炎的指南/专家共识推荐的治疗方案基本一致,为临床用药提供了较为合理的证据。但在抗生素使用、中医治法组合上,需根据临床实际情况进一步探讨验证。

Objective To explore the medication rule of Xiyanping Injection (喜炎平注射液) in the treatment of viral encephalitis based on the real world, and to provide reference for clinical rational drug use. Methods A total of 10 845 electronic medical records of Xiyanping Injection in the treatment of viral encephalitis were extracted from the real world electronic medical database constructed by the Institute of Clinical Basic Medicine of Chinese Medicine, China Academy of Chinese Medical Sciences. Tabu search algorithm and complex network analysis were used to summarize the results and obtain the clinical medication rule. Results A total of 119 kinds of combined Chinese and western drugs with a frequency of use greater than 11 were included, and the best divided 35 drug subgroups and complex network diagram were obtained, which showed the best clinical combined medication characteristics of Xiyanping Injection combined with other drugs in the treatment of viral encephalitis. Conclusion Xiyanping Injection in the treatment of viral encephalitis included antiviral, symptomatic support, complications and sequelae, which were basically consistent with the guidelines of viral encephalitis expert consensus recommended treatment, providing reasonable evidence for clinical drug use. However, the combination of antibiotic use and traditional Chinese medicine treatment needed further discussion and verification according to the clinical situation.

R285.64

中国中医科学院科技创新工程项目（CI2021A00702）；第四批全国中医（西学中）优秀人才研修项目（国中医药办人教函[2019]64）；南京中医药大学自然科学基金项目（XZR2020050）；江苏省卫生健康委科研课题（Z2018005）