目的 研究华东覆盆子Rubus chingii茎的化学成分。方法 利用硅胶、ODS柱色谱、Sephadex LH-20葡聚糖凝胶柱色谱、高效制备液相色谱等色谱方法进行分离纯化,根据理化性质及波谱数据分析鉴定化合物结构。结果 从覆盆子茎中分离得到17个化合物,分别鉴定为松脂素(1)、黑麦草内酯(2)、催吐萝芙木醇(3)、(−)-丁香脂素(4)、13E-对映-半日花烷-8(17),13-二烯-3β,15,18-三醇(5)、3β,18-di-hydroxy-manool(6)、(+)-儿茶素(7)、(−)-儿茶素(8)、邻苯二甲酸二丁酯(9)、goshonoside-F1(10)、3β-hydroxy-manool-18-O-β-D-glucoside(11)、goshonoside-F2(12)、goshonoside-F5(13)、goshonoside-F4(14)、goshonoside-F3(15)、goshonoside-F7(16)、异槲皮素(17)。结论 化合物11为新化合物,命名为覆盆子苷B;化合物6为新的天然产物,化合物1~4为首次从该植物中分离得到,化合物1~17为覆盆子茎中首次分离。

Objective To study the chemical constituents of the stems of Rubus chingii. Methods The chemical constituents were isolated and purified by column chromatography on silica gel, ODS, Sephadex LH-20 and MPLC. Their structures were elucidated on basis of physicochemical properties and spectroscopic analysis. Results Seventeen compounds were isolated from the stems of R. chingii,and identified as pinoresinol (1), loliolide (2), vomifoliol (3), (−)-syringaresinol (4), 13E-ent-labda-8(17),13-diene-3β,15,18-triol (5), 3β,18-di-hydroxy-manool (6), (+)-catechin (7), (−)-catechin (8), dibutylphthalate (9), goshonoside-F1 (10), 3β-hydroxy-manool-18-O-β-D-glucoside (11), goshonoside-F2 (12), goshonoside-F5 (13), goshonoside-F4 (14), goshonoside-F3 (15), goshonoside-F7 (16), isoquercetin (17). Conclusion Compound 11 is a new compound named as goshonoside B and compound 6 is a new natural product, compounds 1-4 were isolated from the plant for the first time, compounds 1-17 were isolated from the stems of R. chingii for the first time.

R284.1

江西省自然科学基金资助项目（20192BAB205115）；江西省中医药标准化项目（2021A05）；江西省卫生健康委科技计划项目（SKJP_220219796）