玉泉丸是治疗糖尿病的经典名方，具有滋肾养阴、益气生津和止渴除烦等功效，现代临床常用来治疗气阴两虚证糖尿病及其并发症等，但对其药效物质基础和药理研究较少。对玉泉丸的化学成分和药理作用的研究情况进行综述，并在此基础上，结合本课题组前期工作基础，基于中药质量标志物（quality marker，Q-Marker）的“五原则”对玉泉丸的Q-Marker进行预测分析，提出葛根素、大豆苷元、地黄苷D、五味子醇甲、五味子乙素、麦冬皂苷D、甘草素、甘草酸和甘草苷可作为玉泉丸的Q-Marker，后续可选择这些成分为指标对玉泉丸进行全程质量控制和评价，并建立质量溯源体系。

Yuquan Pill (玉泉丸) is a classic prescription for the treatment of diabetes, which has the effects of nourishing kidney and nourishing yin, tonifying qi and fluid, relieving thirst and relieving annoyance, etc,. It is often used to treat diabetes and its complications of deficiency of both qi and yin in modern clinic, but there are few studies on the material basis and pharmacology of its efficacy. In this paper, the chemical composition and pharmacological action of Yuquan Pill are reviewed. On this basis, the Q-Marker of Yuquan Pill are also predicted and analyzed based on the "five principles" of traditional Chinese medicine quality marker (Q-Marker). It is suggested that puerarin, daidzein, rehmannioside D, schisandrin, schisandrin B, ophiopogonin D, liquiritigenin, glycyrrhizic acid and liquiritin can be used as Q-Marker of Yuquan Pill. In the follow-up, these components can be selected as indicators for the whole process quality control and evaluation of Yuquan Pills, and at the same time, we can establish the quality traceability system.

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