抑郁症是一种精神障碍性疾病，严重影响患者身心健康。目前抑郁症的临床治疗多以化学药物配合心理咨询为主。抑郁症发病持续周期较长，常用的化学药虽然可以发挥良好的短期疗效，但长期服用会呈现出不同程度的不良反应及耐药性。而中医药在治疗抑郁症等精神类疾病方面历史悠久、经验丰富，其用药强调身心合一的整体观，作用更加持久、缓和、稳定，更适用于抑郁症的长期药物调节。基于中医药理论结合抑郁症发病机制，对近10年来相关抗抑郁中药的作用及其机制加以梳理概括，以期为临床抑郁症的治疗用药提供参考。

Depression is a kind of mental disorder, which seriously affects the physical and mental health of patients. At present, the clinical treatment of depression is primarily based on chemical synthesis drugs combined with psychological counseling. The period of depression usually lasts for a long time, and the commonly used antidepressant drugs in clinical practice are chemical synthesis drugs. Although they have good short-term effect, long-term use will show varying degrees of adverse reactions and drug resistance. In contrast traditional Chinese medicien (TCM) has a long history and rich experience in the treatment of mental diseases including depression. It emphasizes the holistic view of body and mind, and has a lasting, moderate and stable effect, which is more suitable for long-term drug treatment of depression. Based on the theory of TCM combined with the pathogenesis of depression, this paper summarizes the role and mechanism of related antidepressant TCM in the past 10 years, in order to provide the reference for the treatment of clinical depression patients.

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国家自然科学基金青年科学基金项目（82003936）