目的 基于扩展的德亚盖因-兰多-弗韦-奥弗比克（extended Derjaguin-Laudau-Verwey-Overbeek，XDLVO）理论解析蛋白质、鞣质、果胶、淀粉4种中药共性高分子与超滤膜及各高分子之间的界面相互作用，预测其超滤膜污染行为。方法 以蛋白质、果胶、鞣质、淀粉4种中药共性高分子作为模拟污染物进行超滤膜过滤实验。采用XDLVO理论定量分析中药共性高分子与超滤膜之间的界面相互作用，评价极性作用力（AB）、范德华力（LW）、双电层作用力（EL）对超滤膜污染的相对贡献，预测中药共性高分子的超滤膜污染行为，并将XDLVO理论预测结果与膜过滤通量进行比较分析。结果 4种中药共性高分子与超滤膜之间的总界面作用能大小顺序依次为果胶＞淀粉＞鞣质＞蛋白质，且皆为负值，表明4种中药共性高分子与超滤膜之间表现为相互吸引。其中，极性作用力最大，在总界面作用能中占主导地位；双电层作用力最小，其对总界面作用能的影响可以忽略。除果胶-果胶之间相互吸引外，蛋白质-蛋白质、鞣质-鞣质、淀粉-淀粉之间均表现为相互排斥。各高分子溶液的超滤膜通量衰减严重程度依次为果胶＞淀粉＞鞣质＞蛋白质，其与XDLVO理论预测的各高分子膜污染行为相一致。结论 XDLVO理论可以有效地预测中药共性高分子的超滤膜污染行为，为从微观角度分析中药膜污染现象提供了参考借鉴。

Objective The extended Derjaguin-Laudau-Verwey-Overbeek (XDLVO) theory was used to evaluate the interfacial interactions between four common polymers of traditional Chinese medicines (including protein, tannin, pectin, and starch) and ultrafiltration membranes to predict the ultrafiltration membrane fouling behaviors. The predicted results were verified by the membrane filtration experiment. Methods Four common polymers of traditional Chinese medicine such as protein, pectin, tannin and starch were used as simulated pollutants for the ultrafiltration experiment. XDLVO theory was used to quantitatively analyze the interface interaction between common polymers and ultrafiltration membranes, evaluate the relative contributions of polar force (AB), van der Waals force (LW) and electric double layer force (EL) to ultrafiltration membrane fouling, and predict the fouling behavior of common polymers. The predicted results of the XDLVO theory were compared with membrane filtration flux. Results The order of total interfacial interaction energy between the four common polymers and ultrafiltration membrane was pectin > starch > tannin > protein, and all of them were negative, indicating that the four common polymers and ultrafiltration membrane attract each other. The polar force was the most powerful and played a significant role in the total interface energy. The electric double layer force was the smallest, so its impact on total interface energy can be ignored. In addition to the attraction between pectin and pectin, protein-protein, tannin-tannin and starch-starch were mutually exclusive. The severity of ultrafiltration membrane flux attenuation of each polymer solution was pectin > starch > tannin > protein, which was consistent with the pollution behavior of each polymer membrane predicted by XDLVO theory. Conclusion The XDLVO theory can accurately predict the ultrafiltration membrane fouling behavior of common polymers in traditional Chinese medicine, providing a reference for micro-analysis of the membrane fouling phenomena in traditional Chinese medicine.

R283.6

国家自然科学基金项目（81803744）；国家自然科学基金项目（81773919）；国家自然科学基金项目（81873015）；陕西省教育厅重点实验室项目（19JS018）