微针作为一种新兴的制剂形式，具有微创、无痛的优势，可以克服其他经皮递送系统吸收差的潜在缺陷，穿透角质层实现药物递送。中药经皮微针是将中药以微针形式或在微针帮助下输送至真皮层，通过微循环进入血液，到达治疗部位。对固体中药经皮微针、涂层中药经皮微针、可溶性中药经皮微针、水凝胶中药经皮微针和中空中药经皮微针的优缺点和应用进行总结，以期为更多中药经皮微针的开发与临床应用提供参考。

As a new form of preparation, microneedle has the advantages of minimally invasive and painless. It can overcome the potential defects of poor absorption in other percutaneous delivery systems and achieve drug delivery through the cuticle. Traditional Chinese medicine percutaneous microneedles are delivered to dermis in the form of microneedles or with the help of microneedles, which enter the blood through microcirculation and reach the treatment site. The advantages and disadvantages of solid, coated, soluble, hydrogel and hollow traditional Chinese medicine percutaneous microneedles and their applications are summarized in this paper, in order to provide reference for development and clinical application of more traditional Chinese medicine percutaneous microneedles.

R283.3

国家自然科学基金资助项目（82104012）；中国医学科学院医学与健康科技创新工程重大协同创新项目（2021-I2M-1-042）