目的 优化减压煅制白矾的炮制工艺。方法 选择煅制温度、煅制时间和物料厚度为考察因素，以脱水比、硫酸铝钾含量、最低抑菌质量浓度、NO浓度、细胞相对吞噬率为评价指标，采用层次分析（analytic hierarchy process，AHP）-赋值法（criteria importance through intercriteria correlation，CRITIC）混合加权法确定各指标的权重系数，并结合中心组合设计（Box-Behnken）响应面法优化白矾减压煅制工艺。结果 确定了白矾减压煅制的最佳工艺为0.1 MPa的压力下，煅制温度199.798 ℃，煅制时间9.345 min，物料厚度1.424 mm。该条件下煅制的白矾色白，呈蜂窝状，质轻，手捻易碎无结晶，无“夹尘”“结顶”“封皮”“污底”等现象。结论 对减压法煅制白矾的工艺进行了系统的研究，所优选的工艺稳定、可行，重复性好，成品质量高，适合工业化大生产的需求。

Objective To optimize the processing technology of vacuum calcination for alum. Methods The calcined temperature, calcined time and material thickness were selected as investigate factors. The driage, content of aluminium potassium sulfate, minimal inhibitory concentration, NO concentration and relative phagocytic rate of cells were used as evaluation indexes, the weighting coefficient of evaluation indexes was determined by the mixed weighted method of analytic hierarchy process (AHP) and criteria importance through inter criteria correlation (CRITIC). The parameters of processing technology of vacuum calcination of alum were optimized by Box-Behnken response surface test. Results The optimal parameters of processing technology of vacuum calcination alum were as follows: The pressure of vacuum calcination alum was 0.1 MPa, calcined temperature was 199.798 ℃, calcined time was 9.345 min and material thickness was 1.424 mm.The alum calcined under these conditions was white in color, honeycomb in shape, light in weight, easily broken by hand, no crystallization, without "dust", " top binding", "around envelop", "dirt bottom" and other phenomena. Conclusion The processing technology of vacuum calcination for alum is studied systematically in this paper. The optimized processing technology of vacuum calcination is reasonable, stable, reproducible, with good quality of processed products, which can be used for industrialized production.

R283.1

国家重点研发计划项目（2018YFC1707203）